Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Department of the Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Lupus. 2021 Jun;30(7):1108-1115. doi: 10.1177/09612033211005026. Epub 2021 Mar 28.
The systemic lupus erythematosus (SLE) symptom checklist (SSC) is a patient-reported outcome measure consisting of 38 queries. We translated SSC into Japanese and attempted to validate its usefulness for evaluating the quality of life (QOL) of SLE patients and identify factors that affect QOL.
Data from the Medical Outcomes Study Short-form 36 questionnaire (SF-36), Japanese LupusPRO, the Japanese version of the SSC (SSC-J) questionnaire, SLEDAI-2k, and the physician global assessment (PGA) were obtained on the same day from 226 SLE outpatients of the Kyoto Lupus cohort at Kyoto University Hospital. Relationships between the total scores or each item of SSC-J and SF-36, Japanese LupusPRO, SLEDAI-2k, or PGA were analyzed by Spearman's rank test.
The total scores of SSC-J correlated with the scores of SF-36 and Japanese LupusPRO. In each item of SSC-J, all 38 items correlated with the physical component summary and mental component summary of SF-36 as well as the Health-Related QOL (HRQOL) scores of Japanese LupusPRO, but not with the non-HRQOL of LupusPRO. SSC-J scores correlated with age, PGA, and corticosteroid doses, but not with SLEDAI-2k.
SSC-J is suitable as a disease-specific QOL assessment tool for SLE.
系统性红斑狼疮（SLE）症状清单（SSC）是一种包含 38 个问题的患者报告结局测量工具。我们将 SSC 翻译成日语，并尝试验证其用于评估 SLE 患者生活质量（QOL）和识别影响 QOL 的因素的有用性。
从京都大学医院的京都狼疮队列的 226 名 SLE 门诊患者同一天获得了医疗结局研究短表 36 项问卷（SF-36）、日本 LupusPRO、SSC-J 问卷的日语版、SLEDAI-2k 和医生整体评估（PGA）的数据。通过 Spearman 秩检验分析 SSC-J 的总分或每个项目与 SF-36、日本 LupusPRO、SLEDAI-2k 或 PGA 之间的关系。
SSC-J 的总分与 SF-36 和日本 LupusPRO 的得分相关。在 SSC-J 的每个项目中，38 个项目都与 SF-36 的生理成分综合和心理成分综合以及日本 LupusPRO 的健康相关生活质量（HRQOL）评分相关，但与 LupusPRO 的非 HRQOL 不相关。SSC-J 评分与年龄、PGA 和皮质类固醇剂量相关，但与 SLEDAI-2k 无关。
SSC-J 适合作为 SLE 的特定疾病 QOL 评估工具。
