Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Department of Advanced Medicine for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Lupus. 2021 Sep;30(10):1577-1585. doi: 10.1177/09612033211025614. Epub 2021 Jun 14.
It is important to clarify the relationship between irreversible organ damage and the quality of life (QOL) by considering the unique factors of patients with systemic lupus erythematosus (SLE). We aimed to clarify their correlation using SLE-specific QOL assessment tools. We also aimed to identify which type of organ damage is adversely correlated with the QOL.
We conducted a questionnaire-based survey of outpatients with SLE at Kyoto University Hospital and evaluated irreversible organ damage using the SLICC/ACR damage index (SDI). LupusPRO and the SLE symptom checklist (SSC) were employed as SLE-specific QOL tools, and the SF-36v2 was used as a conventional QOL tool. Multiple linear regression analyses were performed to examine the correlations between the total SDI score and each QOL score, and between each SDI item/system score and each QOL score.
We analyzed the data of 265 patients. The total SDI score was significantly correlated with physical (PCS) and role/social component summary (RCS) of the SF-36v2, health-related QOL (HRQOL) of LupusPRO, and SSC ( < 0.001). Among the SDI items, atrophy/weakness and osteoporosis with fracture/vertebral collapse were negatively correlated with PCS (β = -0.40, < 0.001/β = -0.28, < 0.001), RCS (β = -0.30, < 0.001/β = -0.35, < 0.001), and HRQOL (β = -0.34, < 0.001/β = -0.31, < 0.001), respectively. Among the SDI systems, musculoskeletal damage had higher negative correlations with PCS (β = -0.51, < 0.001), RCS (β = -0.29, < 0.001), and HRQOL (β = -0.40, < 0.001).
We demonstrated the QOL of patients with SLE is negatively correlated with irreversible organ damage. We also revealed musculoskeletal damage is adversely correlated with the health-related QOL, especially the physical and role/social QOL.
通过考虑系统性红斑狼疮 (SLE) 患者的独特因素，阐明不可逆性器官损伤与生活质量 (QOL) 之间的关系非常重要。我们旨在使用特定于 SLE 的 QOL 评估工具来阐明它们之间的相关性。我们还旨在确定哪种类型的器官损伤与 QOL 呈负相关。
我们对京都大学医院的 SLE 门诊患者进行了基于问卷的调查，并使用 SLICC/ACR 损伤指数 (SDI) 评估不可逆性器官损伤。LupusPRO 和 SLE 症状检查表 (SSC) 被用作特定于 SLE 的 QOL 工具，SF-36v2 被用作常规 QOL 工具。进行了多元线性回归分析，以检查总 SDI 评分与每个 QOL 评分之间的相关性，以及每个 SDI 项目/系统评分与每个 QOL 评分之间的相关性。
我们分析了 265 名患者的数据。SDI 总分与 SF-36v2 的生理 (PCS) 和角色/社会成分综合评分 (RCS)、LupusPRO 的健康相关 QOL (HRQOL) 和 SSC 显著相关 ( < 0.001)。在 SDI 项目中，萎缩/无力和骨质疏松伴骨折/椎体塌陷与 PCS (β = -0.40, < 0.001/β = -0.28, < 0.001)、RCS (β = -0.30, < 0.001/β = -0.35, < 0.001) 和 HRQOL (β = -0.34, < 0.001/β = -0.31, < 0.001) 呈负相关。在 SDI 系统中，肌肉骨骼损伤与 PCS (β = -0.51, < 0.001)、RCS (β = -0.29, < 0.001) 和 HRQOL (β = -0.40, < 0.001) 的负相关性更高。
我们证明了 SLE 患者的 QOL 与不可逆性器官损伤呈负相关。我们还揭示了肌肉骨骼损伤与健康相关的 QOL，特别是身体和角色/社会 QOL 呈负相关。
