6420Massey University, Palmerston North, New Zealand.
Vet Pathol. 2021 Sep;58(5):841-857. doi: 10.1177/0300985821999832. Epub 2021 Mar 29.
The skeletal system is a common site for neoplasia in dogs and cats, and primary bone tumors may develop from any of the mesenchymal tissues present in bone. Imaging and histopathology are routinely used in the diagnosis of bone tumors, and the 2 techniques are highly complementary. While imaging may be highly suggestive of a specific diagnosis and treatment may be instituted based on this, definitive diagnosis requires histopathology of either incisional or excisional biopsies or an amputation specimen. However, there are a number of diagnostic dilemmas when the pathologist interprets bone biopsy samples, such as distinguishing reactive bone and tumor bone, fracture callus and tumor bone, different benign fibro-osseous lesions, and different types of bone sarcoma. This review outlines the characteristic radiographic and histologic changes associated with these diagnostic problems to aid in resolving them. When a holistic approach is taken to evaluation of the signalment, history, and clinical, radiologic, and microscopic features, a diagnosis may be possible. The pathologist is greatly assisted in the interpretation of bone samples by having access to imaging and should routinely request either the images or the imaging reports if they are not received from submitting veterinarians.
骨骼系统是犬猫肿瘤的常见部位，原发性骨肿瘤可源自骨内任何间叶组织。影像学和组织病理学常用于骨肿瘤的诊断，这两种技术具有高度互补性。虽然影像学可能高度提示特定的诊断，并且可以根据该诊断进行治疗，但明确的诊断需要对切开或切除活检或截肢标本进行组织病理学检查。然而，当病理学家解释骨活检样本时，存在许多诊断难题，例如区分反应性骨和肿瘤骨、骨折骨痂和肿瘤骨、不同的良性纤维骨病变以及不同类型的骨肉瘤。本综述概述了与这些诊断问题相关的特征性放射影像学和组织学变化，以帮助解决这些问题。当对发病年龄、病史以及临床、放射影像学和显微镜下特征进行整体评估时，可能可以做出诊断。如果病理学家无法从送检兽医处获得影像学检查或影像学报告，那么能够获得影像学检查结果将极大地帮助其解释骨样本。
