Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
J Pharm Pharmacol. 2021 Aug 12;73(9):1137-1150. doi: 10.1093/jpp/rgab014.
Isatis indigotica Fort. (I. indigotica) is an herbaceous plant belonging to Cruciferae family. Its leaf (IIL) and root (IIR) are commonly used in traditional Chinese medicines (TCMs) with good clinical efficacies such as clearing away heat and detoxification, cooling blood and reducing swelling. This review aimed to provide a systematic summary on the phytochemistry, pharmacology and clinical applications of I. indigotica.
This plant contains alkaloids, organic acids, flavonoids, lignans, nucleosides, amino acids, and steroids. Previous pharmacological researches indicated that I. indigotica possesses promising antivirus, antibacterial, immunoregulatory, anti-inflammation, and cholagogic effects. Importantly, it can inhibit various viruses, such as influenza, hepatitis B, mumps, herpes simplex, cytomegalovirus, and coxsachievirus. Clinically, it is frequently used to treat various viral diseases like viral influenza, parotitis and viral hepatitis. Consequently, I. indigotica may be beneficial for the prevention and treatment of coronavirus disease 2019 (COVID-19).
This paper reviewed the chemical constituents, pharmacological effects and clinical applications of I. indigotica which may guide further research and application of this plant.
菘蓝（Isatis indigotica Fort.）为十字花科草本植物，其叶（IIL）和根（IIR）在传统中药中被广泛应用，具有良好的临床疗效，如清热解毒、凉血消肿等。本综述旨在对菘蓝的植物化学、药理学和临床应用进行系统总结。
该植物含有生物碱、有机酸、黄酮类、木脂素、核苷、氨基酸和甾体。先前的药理学研究表明，菘蓝具有有希望的抗病毒、抗菌、免疫调节、抗炎和利胆作用。重要的是，它可以抑制多种病毒，如流感、乙型肝炎、腮腺炎、单纯疱疹、巨细胞病毒和柯萨奇病毒。临床上，它常用于治疗各种病毒性疾病，如病毒性流感、腮腺炎和病毒性肝炎。因此，菘蓝可能有助于预防和治疗 2019 年冠状病毒病（COVID-19）。
本文综述了菘蓝的化学成分、药理作用及临床应用，可为该植物的进一步研究和应用提供指导。
