Palliative Care Unit, National Cancer Institute José Alencar Gomes da Silva (INCA), Rua Visconde de Santa Isabel, 274, Vila Isabel, Rio de Janeiro, RJ, 20560-120114, Brazil.
Support Care Cancer. 2021 Oct;29(10):6005-6012. doi: 10.1007/s00520-021-06149-1. Epub 2021 Mar 29.
To describe overall survival (OS) in 90 days and to evaluate the prognostic factors in patients with advanced cancer and COVID-19.
This is a retrospective cohort study carried out at the Palliative Care Unit of the Brazilian National Cancer Institute. Patients with advanced cancer and COVID-19 confirmed by Reverse Transcription Polymerase Chain Reaction were included. Kaplan-Meier's curves, log-rank test, and Cox regression were performed.
Eighty-three inpatients were selected. The average age was 61.4 (±12.6) years, with a higher proportion of women (73.4%). The most prevalent tumor type was breast (36.7%), followed by gastrointestinal tract (20.3%). The OS was 32 [interquartile range (IQR): 6-70] days, and at the end of the follow-up period, 17 patients (20.5%) were alive and 66 (79.5%) had died. Patients with advanced cancer and COVID-19 and who were 60-74 years old [hazard ratio (HR): 2.03; 95% confidence interval (CI): 1.09-3.78], with lung tumors (HR: 17.50; 95% CI: 1.70-28.34), with lung metastasis (HR: 4.21; 95% CI: 2.17-8.15), and with chronic obstructive pulmonary disease (HR: 4.92; 95% CI: 1.01-24.69) had higher risk of death in 90 days.
The age of 60-74 years old, lung tumors (primary or metastases), and the presence of chronic obstructive pulmonary disease were considered independent prognostic factors in patients with advanced cancer and COVID-19.
描述 90 天内的总生存率（OS），并评估患有晚期癌症和 COVID-19 的患者的预后因素。
这是一项在巴西国家癌症研究所姑息治疗病房进行的回顾性队列研究。纳入经逆转录聚合酶链反应（RT-PCR）确诊的晚期癌症合并 COVID-19 的患者。采用 Kaplan-Meier 曲线、对数秩检验和 Cox 回归进行分析。
共纳入 83 例住院患者，平均年龄为 61.4（±12.6）岁，女性比例较高（73.4%）。最常见的肿瘤类型是乳腺癌（36.7%），其次是胃肠道肿瘤（20.3%）。OS 为 32 [四分位间距（IQR）：6-70]天，随访期末，17 例（20.5%）患者存活，66 例（79.5%）患者死亡。年龄在 60-74 岁的晚期癌症合并 COVID-19 患者（风险比[HR]：2.03；95%置信区间[CI]：1.09-3.78）、肺部肿瘤（HR：17.50；95%CI：1.70-28.34）、肺部转移（HR：4.21；95%CI：2.17-8.15）和慢性阻塞性肺疾病（HR：4.92；95%CI：1.01-24.69）的患者在 90 天内死亡的风险更高。
年龄在 60-74 岁、肺部肿瘤（原发性或转移灶）和慢性阻塞性肺疾病与晚期癌症合并 COVID-19 患者的独立预后因素相关。
