Center for Advanced Chemistry, Institute of Research and Development, Duy Tan University, 03 Quang Trung, Da Nang, 50000, Vietnam.
Department of Pharmacy, Duy Tan University, 03 Quang Trung, Da Nang, 50000, Vietnam.
Chem Biodivers. 2021 May;18(5):e2100145. doi: 10.1002/cbdv.202100145. Epub 2021 Apr 21.
Lantana camara is a troublesome invasive plant introduced to many tropical regions, including Southeast Asia. However, the plant does hold promise as a source of essential oils that may be explored for potential use. Fresh water snails such as Pomacea canaliculata, Gyraulus convexiusculus, and Tarebia granifera can be problematic agricultural pests as well as hosts for parasitic worms. Aedes and Culex mosquitoes are notorious vectors of numerous viral pathogens. Control of these vectors is of utmost importance. In this work, the essential oil compositions, molluscicidal, and mosquito larvicidal activities of four collections of L. camara from north-central Vietnam have been investigated. The sesquiterpene-rich L. camara essential oils showed wide variation in their compositions, not only compared to essential oils from other geographical locations (at least six possible chemotypes), but also between the four samples from Vietnam. L. camara essential oils showed molluscicidal activities comparable to the positive control, tea saponin, as well as other botanical agents. The median lethal concentrations (LC ) against the snails were 23.6-40.2 μg/mL (P. canaliculata), 7.9-29.6 μg/mL (G. convexiusculus), and 15.0-29.6 μg/mL (T. granifera). The essential oils showed good mosquito larvicidal activities with 24-h LC values of 15.1-29.0 μg/mL, 26.4-53.8 μg/mL, and 20.8-59.3 μg/mL against Ae. aegypti, Ae. albopictus, and Cx. quinquefasciatus, respectively. The essential oils were more toxic to snails and mosquito larvae than they were to the non-target water bug, Diplonychus rusticus (24-h LC =103.7-162.5 μg/mL). Sesquiterpene components of the essential oils may be acting as acetylcholinesterase (AChE) inhibitors. These results suggest that the invasive plant, L. camara, may be a renewable botanical pesticidal agent.
马缨丹是一种引入许多热带地区（包括东南亚）的有害入侵植物。然而，该植物具有作为精油来源的潜力，可用于探索潜在用途。淡水蜗牛，如Pomacea canaliculata、Gyraulus convexiusculus 和 Tarebia granifera，既是有问题的农业害虫，也是寄生虫的宿主。埃及伊蚊和致倦库蚊是许多病毒病原体的臭名昭著的传播媒介。控制这些媒介至关重要。在这项工作中，研究了来自越南北中部的四个马缨丹种群的精油组成、杀螺和杀蚊幼虫活性。富含倍半萜的马缨丹精油在组成上表现出很大的差异，不仅与其他地理位置的精油（至少有六种可能的化学型）相比，而且与来自越南的四个样本相比也是如此。马缨丹精油表现出与阳性对照茶皂素以及其他植物制剂相当的杀螺活性。对蜗牛的半致死浓度（LC ）为 23.6-40.2 μg/mL（P. canaliculata）、7.9-29.6 μg/mL（G. convexiusculus）和 15.0-29.6 μg/mL（T. granifera）。精油对埃及伊蚊、白纹伊蚊和致倦库蚊具有良好的杀蚊幼虫活性，24 小时 LC 值分别为 15.1-29.0 μg/mL、26.4-53.8 μg/mL 和 20.8-59.3 μg/mL。精油对蜗牛和蚊子幼虫的毒性大于对非靶标水龟，即双翅目 Rusticus（24 小时 LC =103.7-162.5 μg/mL）。精油中的倍半萜成分可能作为乙酰胆碱酯酶（AChE）抑制剂。这些结果表明，入侵植物马缨丹可能是一种可再生的植物性杀虫剂。
