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精油的化学与生物活性:文献综述与来自越南的研究。

Chemistry and Bioactivity of Essential Oils: Literature Survey and from Vietnam.

机构信息

Vietnam National Museum of Nature, Vietnam Academy of Science and Technology (VAST), No. 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi 100803, Vietnam.

Vietnam Academy of Science and Technology (VAST), Graduate University of Science and Technology, No. 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi 100803, Vietnam.

出版信息

Molecules. 2023 Mar 3;28(5):2361. doi: 10.3390/molecules28052361.

Abstract

Using essential oils to control vectors, intermediate hosts, and disease-causing microorganisms is a promising approach. The genus in the family Euphorbiaceae is a large genus, with many species containing large amounts of essential oils, however, essential oil studies are limited in terms of the number of species investigated. In this work, the aerial parts of growing wild in Vietnam were collected and analyzed by gas chromatography/mass spectrometry (GC/MS). A total of 141 compounds were identified in essential oil, in which sesquiterpenoids dominated, comprising 95.4%, including the main components β-caryophyllene (32.8%), germacrene D (11.6%), β-elemene (9.1%), α-humulene (8.5%), and caryophyllene oxide (5.0%). The essential oil of showed very strong biological activities against the larvae of four mosquito species with 24 h LC values in the range of 15.38-78.27 μg/mL, against adults with a 48 h LC value of 10.09 μg/mL, and against ATCC microorganisms with MIC values in the range of 8-16 μg/mL. In order to provide a comparison with previous works, a literature survey on the chemical composition, mosquito larvicidal, molluscicidal, antiparasitic, and antimicrobial activities of essential oils of species was conducted. Seventy-two references (seventy articles and one book) out of a total of two hundred and forty-four references related to the chemical composition and bioactivity of essential oils of species were used for this paper. The essential oils of some species were characterized by their phenylpropanoid compounds. The experimental results of this research and the survey of the literature showed that essential oils have the potential to be used to control mosquito-borne and mollusk-borne diseases, as well as microbial infections. Research on unstudied species is needed to search for species with high essential oil contents and excellent biological activities.

摘要

利用精油控制病媒、中间宿主和致病微生物是一种很有前途的方法。大戟科大戟属是一个大属,许多物种含有大量的精油,然而,精油的研究在调查的物种数量方面是有限的。在这项工作中,收集了越南野生生长的大戟属植物的地上部分,并通过气相色谱/质谱(GC/MS)进行了分析。在大戟属植物精油中鉴定出了 141 种化合物,其中倍半萜类化合物占主导地位,占 95.4%,包括主要成分β-石竹烯(32.8%)、大根香叶烯 D(11.6%)、β-榄香烯(9.1%)、α-葎草烯(8.5%)和石竹烯氧化物(5.0%)。大戟属植物精油对四种蚊子幼虫具有很强的生物活性,24 小时 LC 值范围为 15.38-78.27μg/mL,对成蚊的 48 小时 LC 值为 10.09μg/mL,对 ATCC 微生物的 MIC 值范围为 8-16μg/mL。为了与以前的工作进行比较,对大戟属植物精油的化学成分、杀蚊幼虫、杀软体动物、抗寄生虫和抗菌活性进行了文献调查。从总共 244 篇与大戟属植物精油的化学成分和生物活性相关的参考文献中,选取了 72 篇文献(70 篇文章和 1 本书)用于本文。一些大戟属植物的精油以其苯丙烷类化合物为特征。本研究的实验结果和文献调查表明,大戟属植物精油具有控制蚊媒和贝类传播疾病以及微生物感染的潜力。需要对未研究的大戟属物种进行研究,以寻找具有高精油含量和优良生物活性的物种。

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