Institute of Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, 250062, China; Department of Cancer Biology, Cardinal Bernardin Cancer Center, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 60153, United States.
Department of Cancer Biology, Cardinal Bernardin Cancer Center, Loyola University Chicago Stritch School of Medicine, Maywood, IL, 60153, United States.
DNA Repair (Amst). 2021 Jun;102:103104. doi: 10.1016/j.dnarep.2021.103104. Epub 2021 Mar 22.
The human CST (CTC1-STN1-TEN1) complex is an RPA-like single-stranded DNA binding protein complex. While its telomeric functions have been well investigated, numerous studies have revealed that hCST also plays important roles in maintaining genome stability beyond telomeres. Here, we review and discuss recent discoveries on CST in various global genome maintenance pathways, including findings on the CST supercomplex structure, its functions in unperturbed DNA replication, stalled replication, double-strand break repair, and the ATR-CHK1 activation pathway. By summarizing these recent discoveries, we hope to offer new insights into genome maintenance mechanisms and the pathogenesis of CST mutation-associated diseases.
人类 CST（CTC1-STN1-TEN1）复合物是一种类似于 RPA 的单链 DNA 结合蛋白复合物。虽然其端粒功能已得到充分研究，但许多研究表明 hCST 在外显子中也在维持基因组稳定性方面发挥着重要作用。在这里，我们综述和讨论了 CST 在各种全基因组维持途径中的最新发现，包括 CST 超复合物结构、在未受干扰的 DNA 复制、复制停滞、双链断裂修复和 ATR-CHK1 激活途径中的功能。通过总结这些最新发现，我们希望为基因组维持机制和 CST 突变相关疾病的发病机制提供新的见解。
