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服用苯二氮䓬类药物患者的健康相关生活质量

[Health-related quality of life in patients consuming benzodiazepine].

作者信息

García Atienza Eva María, López-Torres Hidalgo Jesús, Minuesa García María, Ruipérez Moreno María, Lucas Galán Francisco Javier, Agudo Mena José Luis

机构信息

Servicio de Urgencias, Hospital General de Villarrobledo, Servicio de Salud de Castilla-La Mancha, AlbaceteEspaña.

Centro de Salud Zona VIII de Albacete, Servicio de Salud de Castilla-La Mancha, España.

出版信息

Aten Primaria. 2021 May;53(5):102041. doi: 10.1016/j.aprim.2021.102041. Epub 2021 Mar 26.

DOI:10.1016/j.aprim.2021.102041
PMID:33780900
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8041718/
Abstract

OBJECTIVE

To describe the health-related quality of life (HRQoL) in benzodiazepine users and to verify whether there is an association with the characteristics of the treatment, its effectiveness, and the sociodemographic variables.

DESIGN

Descriptive cross-sectional study.

LOCATION

Family medicine consultations.

PARTICIPANTS

Four hundred and fifty 2patients over 18 years of age consuming benzodiazepines or similar drugs.

MAIN MEASUREMENTS

HRQoL was assessed using the EuroQol5-D questionnaire. Other variables: symptoms of anxiety or insomnia, sociodemographic variables and characteristics of the treatment.

RESULTS

The mean score in health status was 62.80 (95% CI: 60.69-64.86), lower in people without studies (59.27±21.97 SD; P=.004) and lower social category (60.02±21.27 SD; P<.001). Regarding the social rate (EQ index), a mean score of 0.6025 (95% CI: 0.5659-0.6391) was obtained, higher in people with higher education (0.6577±0.3574 SD; P=.001), plus social category (0.7286±0.3381 SD; P<.001) and age less than 65 years (0.6603±0.3426 SD; P<.001). The variables that were associated with the value of the EQ index by means of multiple regression were absence of anxiety/insomnia, belonging to higher social classes, age less than 65 years and less consumption of anxiolytics/hypnotics.

CONCLUSIONS

Patients who use benzodiazepines show, despite treatment, a moderate HRQL, lower than that obtained in the general population or in primary care patients. The situation is more favorable in the youngest, in those who do not present anxiety/insomnia, in those belonging to higher social classes and when the consumption of drugs is lower.

摘要

目的

描述苯二氮䓬类药物使用者的健康相关生活质量(HRQoL),并验证其与治疗特征、疗效以及社会人口统计学变量之间是否存在关联。

设计

描述性横断面研究。

地点

家庭医学咨询门诊。

参与者

450名18岁以上服用苯二氮䓬类药物或类似药物的患者。

主要测量指标

使用欧洲五维健康量表(EuroQol5-D)问卷评估HRQoL。其他变量:焦虑或失眠症状、社会人口统计学变量以及治疗特征。

结果

健康状况的平均得分为62.80(95%置信区间:60.69 - 64.86),未受过教育者得分较低(59.27±21.97标准差;P = 0.004),社会阶层较低者得分也较低(60.02±21.27标准差;P < 0.001)。关于社会比率(EQ指数),平均得分为0.6025(95%置信区间:0.5659 - 0.6391),受过高等教育者得分较高(0.6577±0.3574标准差;P = 0.001),社会阶层较高者得分较高(0.7286±0.3381标准差;P < 0.001),年龄小于65岁者得分较高(0.6603±0.3426标准差;P < 0.001)。通过多元回归与EQ指数值相关的变量包括无焦虑/失眠、属于较高社会阶层、年龄小于65岁以及抗焦虑药/催眠药消费量较低。

结论

使用苯二氮䓬类药物的患者尽管接受了治疗,但HRQL仍处于中等水平,低于普通人群或初级保健患者。在最年轻的人群、无焦虑/失眠症状者、社会阶层较高者以及药物消费量较低者中,情况更为有利。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d5e/8041718/13a9d1a581a5/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d5e/8041718/13a9d1a581a5/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d5e/8041718/13a9d1a581a5/fx1.jpg

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