Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Department of Cardiology, Kailuan General Hospital, Tangshan, China.
Obes Facts. 2021;14(2):190-196. doi: 10.1159/000514848. Epub 2021 Mar 29.
Nonalcoholic fatty liver disease (NAFLD) is defined by the accumulation of triglycerides (TG). The body mass index (BMI) is associated with NAFLD. This large-scale cohort study was performed to evaluate and quantify the mediating effect of TG on the association between BMI and NAFLD.
In total, 15,943 participants in the Kailuan Group were recruited between 2010 and 2014. The impact of TG on the association between BMI and NAFLD was determined through a mediation analysis.
BMI was an independent risk factor for incident NAFLD, with OR of 1.416 (95% CI 1.338-1.499) and 1.187 (95% CI 1.137-1.240) in the low-BMI and high-BMI groups, respectively (p < 0.001). The TG level was a risk factor for NAFLD in the high-BMI group, with an OR of 2.775 (95% CI 1.488-5.177; p = 0.001). Positive associations between BMI and the TG level remained in the 2 above mentioned groups after adjusting for confounders (β = 0.072 and 0.032; p < 0.001). The mediation analysis revealed that TG contributed to 26.050% of incident NAFLD in the high-BMI group (p = 0.01).
A high BMI was an independent risk factor for incident NAFLD, and a high TG level was a risk factor in the high-BMI group (BMI ≥24). TG contributes about 25% to incident NAFLD in people with obesity.
非酒精性脂肪性肝病 (NAFLD) 的定义是甘油三酯 (TG) 的积累。身体质量指数 (BMI) 与 NAFLD 有关。这项大规模队列研究旨在评估和量化 TG 对 BMI 与 NAFLD 之间关联的中介作用。
共纳入 2010 年至 2014 年间的开滦集团 15943 名参与者。通过中介分析确定 TG 对 BMI 和 NAFLD 之间关联的影响。
BMI 是发生 NAFLD 的独立危险因素，低 BMI 组和高 BMI 组的 OR 分别为 1.416（95%CI 1.338-1.499）和 1.187（95%CI 1.137-1.240）（p<0.001）。高 BMI 组的 TG 水平是 NAFLD 的危险因素，OR 为 2.775（95%CI 1.488-5.177；p=0.001）。在调整混杂因素后，上述两组中 BMI 与 TG 水平之间仍存在正相关（β=0.072 和 0.032；p<0.001）。中介分析显示，高 BMI 组中 TG 导致 26.050%的新发 NAFLD（p=0.01）。
高 BMI 是发生 NAFLD 的独立危险因素，高 TG 水平是高 BMI 组（BMI≥24）的危险因素。在肥胖人群中，TG 约占新发 NAFLD 的 25%。
