Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Jiroft University of Medical Sciences, Jiroft, Iran.
Curr Med Chem. 2021 Oct 27;28(34):7122-7140. doi: 10.2174/0929867328666210329123449.
Curcumin, a yellow pigment in Asian spice, is a natural polyphenol component of Curcuma longa rhizome. Curcuminoid components include curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC). Previous studies established curcumin as a safe agent based on preclinical and clinical evaluations and curcuminoids have been approved by the US Food and Drug Administration (FDA) as "Generally Recognized as Safe" (GRAS). The present review collects and summarizes clinical and preclinical studies of curcumin interactions, with an emphasis on the effect of curcumin and curcumin analogs on the mRNA and protein levels of microsomal CYP450 enzymes (phase I metabolism) and their interactions with toxicants, drugs and drug probes. The literature search was conducted using keywords in various scientific databases, including Web of Science, Scopus, PubMed, and Google Scholar. Studies concerning the impact of curcumin and curcumin analogs on microsomal enzyme activity are reviewed and include oral, topical, and systemic treatment in humans and experimental animals, as well as studies from in vitro research. When taken together, the data identified some inconsistent results between various studies. The findings showed significant inhibition of CYP450 enzymes by curcumin and its analogs. However, such effects are often differed when curcumin and curcumin analogs were coadministered with toxicant and other drugs and drug probes. We conclude from this review that herb-drug interactions should be considered when curcumin and curcumin analogs are consumed.
姜黄，亚洲香料中的黄色色素，是姜黄根茎中的一种天然多酚成分。姜黄素类成分包括姜黄素、脱甲氧基姜黄素（DMC）和双脱甲氧基姜黄素（BDMC）。先前的研究基于临床前和临床评估，确定姜黄是一种安全的药物，姜黄素类已被美国食品和药物管理局 (FDA) 批准为“一般认为是安全的” (GRAS)。本综述收集并总结了姜黄相互作用的临床前和临床研究，重点介绍了姜黄及其类似物对细胞色素 P450 酶（I 相代谢）的 mRNA 和蛋白水平的影响，以及它们与毒物、药物和药物探针的相互作用。文献检索使用了各种科学数据库中的关键词，包括 Web of Science、Scopus、PubMed 和 Google Scholar。综述了关于姜黄和姜黄素类似物对微粒体酶活性影响的研究，包括人类和实验动物的口服、局部和全身治疗，以及体外研究。综合来看，这些数据在不同研究之间存在一些不一致的结果。研究结果表明姜黄及其类似物对 CYP450 酶有明显的抑制作用。然而，当姜黄和姜黄素类似物与毒物和其他药物及药物探针同时给药时，这种作用往往不同。我们从这项综述中得出结论，当食用姜黄和姜黄素类似物时，应考虑草药-药物相互作用。
