State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
School of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Int J Mol Sci. 2023 Feb 7;24(4):3323. doi: 10.3390/ijms24043323.
Metabolic diseases have become a serious threat to human health worldwide. It is crucial to look for effective drugs from natural products to treat metabolic diseases. Curcumin, a natural polyphenolic compound, is mainly obtained from the rhizomes of the genus . In recent years, clinical trials using curcumin for the treatment of metabolic diseases have been increasing. In this review, we provide a timely and comprehensive summary of the clinical progress of curcumin in the treatment of three metabolic diseases, namely type 2 diabetes mellitus (T2DM), obesity and non-alcoholic fatty liver disease (NAFLD). The therapeutic effects and underlying mechanisms of curcumin on these three diseases are presented categorically. Accumulating clinical evidence demonstrates that curcumin has good therapeutic potential and a low number of side effects for the three metabolic diseases. It can lower blood glucose and lipid levels, improve insulin resistance and reduce inflammation and oxidative stress. Overall, curcumin may be an effective drug for the treatment of T2DM, obesity and NAFLD. However, more high-quality clinical trials are still required in the future to verify its efficacy and determine its molecular mechanisms and targets.
代谢性疾病已成为全球范围内人类健康的严重威胁。寻找有效的天然产物药物来治疗代谢性疾病至关重要。姜黄素是一种天然多酚化合物，主要从姜黄属植物的根茎中提取。近年来，使用姜黄素治疗代谢性疾病的临床试验不断增加。在本综述中，我们及时全面地总结了姜黄素在治疗三种代谢性疾病（即 2 型糖尿病（T2DM）、肥胖和非酒精性脂肪性肝病（NAFLD））方面的临床进展。姜黄素对这三种疾病的治疗效果和潜在机制进行了分类阐述。越来越多的临床证据表明，姜黄素在治疗这三种代谢性疾病方面具有良好的治疗潜力和较低的副作用。它可以降低血糖和血脂水平，改善胰岛素抵抗，减轻炎症和氧化应激。总的来说，姜黄素可能是治疗 T2DM、肥胖和 NAFLD 的有效药物。然而，未来仍需要更多高质量的临床试验来验证其疗效，并确定其分子机制和靶点。
