Univ Lyon, University Claude Bernard Lyon-1, CNRS, ISA-UMR 5280, 69622 Villeurbanne, France; Environmental Process Engineering Laboratory, University Constantine 3, Salah Boubnider, Constantine, Algeria.
Environmental Process Engineering Laboratory, University Constantine 3, Salah Boubnider, Constantine, Algeria.
Int J Pharm. 2021 May 15;601:120538. doi: 10.1016/j.ijpharm.2021.120538. Epub 2021 Mar 27.
The last decade has witnessed a burgeoning global movement towards essential and vegetable oils in the food, agriculture, pharmaceutical, cosmetic, and textile industries thanks to their natural and safe status, broad acceptance by consumers, and versatile functional properties. However, efforts to develop new therapy or functional agents based on plant oils have met with challenges of limited stability and/or reduced efficacy. As a result, there has been increased research interest in the encapsulation of plant oils, whereby the nanocarriers serve as barrier between plant oils and the environment and control oil release leading to improved efficacy, reduced toxicity and enhanced patient compliance and convenience. In this review, special concern has been addressed to the encapsulation of essential and vegetable oils in three types of nanocarriers: polymeric nanoparticles, liposomes and solid lipid nanoparticles. First, the chemical composition of essential and vegetable oils was handled. Moreover, we gather together the research findings reported by the literature regarding the different techniques used to generate these nanocarriers with their significant findings. Finally, differences and similarities between these nanocarriers are discussed, along with current and future applications that are warranted by their structures and properties.
在过去的十年中，由于其天然和安全的地位、消费者的广泛接受以及多功能的特性，油脂在食品、农业、制药、化妆品和纺织行业的需求日益增长。然而，基于植物油脂开发新疗法或功能性药物的努力面临着稳定性有限和/或功效降低的挑战。因此，人们对植物油脂的包封越来越感兴趣，纳米载体作为植物油脂与环境之间的屏障，控制油脂的释放，从而提高功效、降低毒性、增强患者的顺应性和便利性。在这篇综述中，特别关注了三种类型的纳米载体：聚合物纳米粒子、脂质体和固体脂质纳米粒子对精油和植物油的包封。首先，处理了精油和植物油的化学组成。此外，我们收集了文献中报道的关于使用不同技术生成这些纳米载体的研究结果及其重要发现。最后，讨论了这些纳米载体之间的差异和相似之处，以及它们的结构和性质所保证的当前和未来的应用。
