Guangzhou Women and Children's Medical Center Affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China.
Prenat Diagn. 2021 May;41(6):766-771. doi: 10.1002/pd.5942. Epub 2021 Apr 5.
To review the prenatal and postnatal clinical characteristics and pathological subtypes, as well as the surgical outcome for congenital mesoblastic nephroma (CMN) cases.
A retrospective review was performed in 11 cases with CMN prenatally diagnosed at a single center between 2015 and 2019. The clinical characteristics, surgical outcome, histopathology, and follow-up were retrospectively obtained and reviewed.
The median gestational age at which the sonographic diagnosis was made was 35 weeks. Polyhydramnios was found in four (36.4%) cases, and all resulted in a preterm birth. Nine infants had hypertension. Ten cases underwent radical nephrectomy, and one underwent radical nephrectomy and partial adrenalectomy. The pathological results showed that six tumors were classical variants, four mixed variants, and one was a cellular variant. Three cases presented as a stage I, eight as stage II, and no stage III or IV cases were diagnosed. All patients are alive so far. At a median follow-up of 14 months, no local recurrence, or remote metastases were found.
The prognosis of prenatal CMN cases is excellent after early surgery.
回顾先天性中胚层肾瘤（CMN）病例的产前和产后临床特征及病理亚型，以及手术结果。
对 2015 年至 2019 年在一家单中心经产前诊断为 CMN 的 11 例病例进行回顾性分析。回顾性收集并分析了临床特征、手术结果、组织病理学和随访情况。
超声诊断的中位孕龄为 35 周。4 例（36.4%）存在羊水过多，均导致早产。9 例婴儿患有高血压。10 例患者行根治性肾切除术，1 例患者行根治性肾切除术和部分肾上腺切除术。病理结果显示，6 例为经典型变异，4 例为混合型变异，1 例为细胞型变异。3 例分期为 I 期，8 例分期为 II 期，无 III 期或 IV 期病例。所有患者均存活至今。中位随访 14 个月时，未发现局部复发或远处转移。
早期手术治疗后，产前 CMN 病例的预后良好。
