Department of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, Lublin, Poland.
Independent Laboratory of Behavioral Studies, Medical University of Lublin, Lublin, Poland.
Crit Rev Food Sci Nutr. 2022;62(24):6742-6760. doi: 10.1080/10408398.2021.1905604. Epub 2021 Mar 30.
Neuroinflammation is a key process in the pathogenesis of many neurological disorders, i.e. Alzheimer's disease and Parkinson's disease. However, there are no anti-inflammatory medical interventions recommended so far in the treatment of neuroinflammation-related brain disorders. Therefore, the burden of searching for effective and safe antineuroinflammatory agents is well founded, especially in the aging society. Compounds of plant origin, mainly (poly)phenols, have attracted considerable attention in recent years. Notably, the role of flavonoids in ameliorating neuroinflammation is in the limelight. Thus, we used comprehensive literature retrieval to summarize the effects and active components of edible fruits and their phenolic compounds. As a result, this review presents a valuable summary of results of in vitro, ex vivo, and in vivo studies on the antineuroinflammatory effects of edible fruits and their (poly)phenolic extracts as well as dietary flavonoids and other selected (poly)phenols based on the detailed description of foregoing studies. Additionally, problems resulting from the limited bioavailability of (poly)phenols were discussed.
神经炎症是许多神经紊乱疾病（如阿尔茨海默病和帕金森病）发病机制中的关键过程。然而，迄今为止，在治疗与神经炎症相关的脑部疾病时，并没有推荐使用抗炎的医学干预措施。因此，寻找有效和安全的抗神经炎症剂的负担是合理的，特别是在老龄化社会中。植物来源的化合物，主要是（多）酚类化合物，近年来引起了相当大的关注。值得注意的是，类黄酮在改善神经炎症中的作用备受关注。因此，我们使用全面的文献检索来总结可食用水果及其酚类化合物的作用和活性成分。因此，本综述根据对以往研究的详细描述，提供了关于食用水果及其（多）酚提取物以及膳食类黄酮和其他选定（多）酚的抗神经炎症作用的体外、离体和体内研究结果的有价值的总结。此外，还讨论了（多）酚类化合物生物利用度有限所带来的问题。
