Department of Radiation Oncology, E-DA Hospital, Kaohsiung City, Taiwan.
Department of Medical Imaging and Radiological Sciences, I-Shou University, Kaohsiung City, Taiwan.
J Radiat Res. 2021 May 12;62(3):438-447. doi: 10.1093/jrr/rrab008.
Nasopharyngeal cancer shows a good response to intensity-modulated radiotherapy. However, there is no clear evidence for the benefits of routine use of image-guided radiotherapy. The purpose of this study was to perform a retrospective investigation of the treatment outcomes, treatment-related complications and prognostic factors for nasopharyngeal cancer treated with intensity-modulated radiotherapy and image-guided radiotherapy techniques. Retrospective analysis was performed on 326 consecutive nasopharyngeal cancer patients treated between 2004 and 2015. Potentially significant patient-related and treatment-related variables were analyzed. Radiation-related complications were recorded. The 5-year overall survival and disease-free survival rates of these patients were 77.9% and 70.5%, respectively. Age, AJCC (American Joint Committee on Cancer) stage, retropharyngeal lymphadenopathy, treatment interruption and body mass index were independent prognostic factors for overall survival. Age, AJCC stage, retropharyngeal lymphadenopathy, image-guided radiotherapy and body mass index were independent prognostic factors for disease-free survival. In conclusion, intensity-modulated radiotherapy significantly improves the treatment outcomes of nasopharyngeal cancer. With the aid of image-guided radiotherapy, the advantage of intensity-modulated radiotherapy might be further amplified.
鼻咽癌对强度调制放疗有良好的反应。然而，常规使用图像引导放疗的益处尚无明确证据。本研究旨在对接受强度调制放疗和图像引导放疗技术治疗的鼻咽癌患者的治疗结果、与治疗相关的并发症和预后因素进行回顾性调查。对 2004 年至 2015 年间连续治疗的 326 例鼻咽癌患者进行回顾性分析。分析了潜在的有意义的与患者相关和与治疗相关的变量。记录了与辐射相关的并发症。这些患者的 5 年总生存率和无病生存率分别为 77.9%和 70.5%。年龄、AJCC（美国癌症联合委员会）分期、咽后淋巴结病、治疗中断和体重指数是总生存率的独立预后因素。年龄、AJCC 分期、咽后淋巴结病、图像引导放疗和体重指数是无病生存率的独立预后因素。总之，强度调制放疗显著改善了鼻咽癌的治疗效果。在图像引导放疗的辅助下，强度调制放疗的优势可能进一步放大。
