BASF SE, Synthesis and Homogeneous Catalysis, Carl-Bosch Straße 38, 67056, Ludwigshafen, Germany.
BASF SE, New Business Development Aroma Ingredients, Carl-Bosch Straße 38, 67056, Ludwigshafen, Germany.
Chemistry. 2021 Jun 25;27(36):9263-9266. doi: 10.1002/chem.202005324. Epub 2021 May 21.
A direct carbonylation of allylic alcohols has been realized for the first time with high catalyst activity at low pressure of CO (10 bar). The procedure is described in detail for the carbonylation of E-nerolidol, an important step in a new BASF-route to (-)-ambrox. Key to high activities in the allylic alcohol carbonylation is the finding that catalytic amounts of carboxylic anhydride activate the substrate and are constantly regenerated with carbon monoxide under the reaction conditions. The identified reaction conditions are transferrable to other substrates as well.
首次实现了在低压 CO（10 巴）下具有高催化活性的烯丙醇的直接羰基化。详细描述了 E-橙花叔醇的羰基化反应，这是巴斯夫生产（-）- Ambrox 新路线的重要步骤。在烯丙醇羰基化反应中，关键的是发现催化量的羧酸酐可以激活底物，并在反应条件下不断与一氧化碳再生。确定的反应条件也可以转移到其他底物上。
