Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen, Fujian Province, 361021, PR China.
Fujian Provincial Key Laboratory of Biochemical Technology, Huaqiao University, Xiamen, Fujian Province, 361021, PR China.
Mol Nutr Food Res. 2021 May;65(9):e2000869. doi: 10.1002/mnfr.202000869. Epub 2021 Apr 14.
Degraded porphyran is a bioactive polysaccharide extracted from Porphyra haitanensis (P. haitanensis). According to the previous studies, it produced anti-inflammatory activity, but little is known about its effects on depression.
As inflammation is one of the critical factors involved in the development of depression, this study aims to elucidate the potential antidepressant-like effects of degraded porphyran. The results show that acute porphyran treatment decreased the immobility time in despair tests. In addition, subchronic porphyran administration reverses depressive-like behaviors in lipopolysaccharide (LPS)-treated mice. Meanwhile, porphyran inhibits NF-κB/NLRP3 signaling, proinflammatory cytokine release, and microglial activation in the hippocampus. Moreover, chronic porphyran treatment activates hippocampal brain derived neurotrophic factor (BDNF)/TrkB/ERK/CREB signaling pathway in chronic unpredictable mild stress (CUMS) in mice. As a result, neurogenesis and spinogenesis are maintained.
The findings of the present study indicate that degraded porphyran intake provides a potential strategy for depression treatment, which is mediated by the inhibition of neuroinflammation and the enhancement of neurogenesis and spinogenesis in the central nervous systems.
降解紫菜多糖是从紫菜（Porphyra haitanensis）中提取的一种具有生物活性的多糖。根据以往的研究，它具有抗炎活性，但对其抗抑郁作用知之甚少。
由于炎症是抑郁症发展过程中的关键因素之一，本研究旨在阐明降解紫菜多糖的潜在抗抑郁样作用。结果表明，急性紫菜多糖处理可减少绝望试验中的不动时间。此外，亚慢性紫菜多糖给药可逆转脂多糖（LPS）处理的小鼠的抑郁样行为。同时，紫菜多糖抑制海马中 NF-κB/NLRP3 信号、促炎细胞因子释放和小胶质细胞激活。此外，慢性紫菜多糖处理可激活慢性不可预测轻度应激（CUMS）小鼠海马中的脑源性神经营养因子（BDNF）/TrkB/ERK/CREB 信号通路。结果，神经发生和棘突发生得以维持。
本研究结果表明，摄入降解紫菜多糖通过抑制中枢神经系统的神经炎症、增强神经发生和棘突发生，为抑郁症的治疗提供了一种潜在策略。
