Lee T Y, Lam T H
Caritas Medical Centre and United Christian Hospital, Kowloon, Hong Kong.
Contact Dermatitis. 1988 Apr;18(4):213-8. doi: 10.1111/j.1600-0536.1988.tb02806.x.
A Chinese herbal medicine Lu-Shen-Wan, which contains 6 ingredients, is sometimes applied topically to treat boils, carbuncles and other skin infections. 2 elderly women developed a rash after applying Lu-Shen-Wan. Patch tests showed positive reactions to Lu-Shen-Wan and to one of its 6 ingredients, Venenum Bufonis. A study in 15 control patients showed that 13 had positive reactions to 50% Lu-Shen-Wan and 50% Venenum Bufonis but that only 2 showed mild reactions when the concentration of the latter was reduced to 5%. The results suggest that Venenum Bufonis in Lu-Shen-Wan can cause irritant contact dermatitis. The present paper demonstrates that a Western dermatological investigative method, the patch test, is applicable to traditional medicine in confirming the cause of contact dermatitis from a Chinese herbal preparation and in identifying the causative ingredient. Such knowledge is very useful for the improvement of the preparation by reducing the concentration of the irritant, by removing it or by substituting it with an alternative non-irritant substance.
一种含有6种成分的中药六神丸，有时用于局部治疗疔疮、痈疽及其他皮肤感染。两名老年女性在使用六神丸后出现皮疹。斑贴试验显示对六神丸及其6种成分之一蟾酥呈阳性反应。对15名对照患者的一项研究表明，13人对50%六神丸和50%蟾酥呈阳性反应，但当后者浓度降至5%时，只有2人出现轻度反应。结果表明，六神丸中的蟾酥可引起刺激性接触性皮炎。本文证明，西方皮肤病学研究方法——斑贴试验，可应用于传统医学，以确认中草药制剂引起接触性皮炎的原因，并确定致病成分。这些知识对于通过降低刺激性成分的浓度、去除该成分或用替代的无刺激性物质替代它来改进制剂非常有用。
