Serup J, Staberg B
Department of Dermatology, Gentofte Hospital, Copenhagen, Denmark.
Contact Dermatitis. 1987 Aug;17(2):80-4. doi: 10.1111/j.1600-0536.1987.tb02665.x.
The oedema formation of patch test reactions was quantified by high-frequency ultrasound measurement of skin thickness. Patch testing with nickel sulphate, nickel chloride and sodium lauryl sulphate 1, 2, 5 and 10% was performed in 12 individuals with known nickel allergy. Oedema was greater in allergic than in irritant reactions similar in strength according to the clinical reading. In allergic reactions, the oedema appeared more transcutaneous, while in irritant reactions, more superficial. For differentiation of the 2 types of reaction, application of substances for a 24-h period with measurements the following day is preferable. For rating of allergic and irritant reactions, 48 h of application is preferable with measurements performed on the day patches are removed.
通过高频超声测量皮肤厚度对斑贴试验反应的水肿形成进行定量。对12名已知对镍过敏的个体进行了1%、2%、5%和10%的硫酸镍、氯化镍和月桂醇硫酸酯钠的斑贴试验。根据临床读数，在强度相似的情况下，过敏反应中的水肿比刺激性反应中的水肿更严重。在过敏反应中，水肿似乎更多地经皮出现，而在刺激性反应中，水肿更表浅。为了区分这两种类型的反应，最好将物质敷用24小时，次日进行测量。对于过敏和刺激性反应的评级，最好敷用48小时，并在去除贴片当天进行测量。
