Wang Zheng, Li Xiang, Xu Ying
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China; Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, 200120 Shanghai, China.
Hebei Agricultural University, Hebei, China.
Transl Oncol. 2021 Jun;14(6):101082. doi: 10.1016/j.tranon.2021.101082. Epub 2021 Mar 27.
Gastric cancer (GC) is common in East Asia and South and Central America. Most GC patients miss the opportunities for surgery. Despite their therapeutic potential, immune checkpoint inhibitors (ICIs) only work in part of patients with GC. Thus, this study was aimed at constructing a signature for diagnosis, prognosis, and prediction of response to ICIs. A multivariate analysis showed that the 8-immune-related-gene (IRG) signature was an independent prognostic factor of overall survival among GC patients. In the high-risk group of 8IRG signature risk score, the fractions of CD4 T cells, macrophage M2 and monocyte, which is associated with the progression of cancers, were higher. The low-risk group had a higher immunophenoscore, which meant a better response to ICIs.
胃癌（GC）在东亚以及南美洲和中美洲很常见。大多数GC患者错失了手术机会。尽管免疫检查点抑制剂（ICI）具有治疗潜力，但仅对部分GC患者有效。因此，本研究旨在构建一个用于诊断、预后以及预测ICI反应的特征标志物。多变量分析显示，8个免疫相关基因（IRG）特征标志物是GC患者总生存的独立预后因素。在8IRG特征标志物风险评分的高危组中，与癌症进展相关的CD4 T细胞、巨噬细胞M2和单核细胞比例更高。低危组具有更高的免疫表型评分，这意味着对ICI的反应更好。
