Gendenshteĭn E I, Lemkina S M, Sernov L N
Farmakol Toksikol. 1985 Nov-Dec;48(6):83-6.
It has been demonstrated in experiments on 420 rats that antiadrenergic, antihistamine, antihypoxic, anabolic, antiarrhythmic and diuretic agents have different effects on the cardiotoxicity of strophanthine K for intact animals and in experimental heart insufficiency of different genesis. The pharmacological analysis revealed some risk factors capable of provoking glycoside intoxication in circulatory failure. Approaches to the goal-oriented drug correction of the risk factors are proposed.
在对420只大鼠进行的实验中已证明，抗肾上腺素能药、抗组胺药、抗缺氧药、同化激素类药、抗心律失常药和利尿药，对毒毛花苷K对正常动物及不同成因的实验性心脏功能不全时的心脏毒性有不同影响。药理学分析揭示了一些在循环衰竭时可引发糖苷中毒的危险因素。并提出了针对这些危险因素进行有针对性药物纠正的方法。
