Shimanovskiĭ N L, Bolotva E N, Volkov A F, Manuĭlov K K
Farmakol Toksikol. 1988 Mar-Apr;51(2):94-7.
It was found that a preliminary administration of phenobarbital to rats caused an increase of the rate of 125I-bilignost excretion in the bile by 46.6% but reduced its half-life in the blood by 48.3% and its excretion in the urine by 46.4%. Phenobarbital decreased the rate of 125I-bilignost absorption by the liver slices and increased the rate of release from them.
研究发现，预先给大鼠注射苯巴比妥，可使胆汁中125I-必利胆的排泄率提高46.6%，但使其在血液中的半衰期缩短48.3%，尿液排泄量减少46.4%。苯巴比妥降低了肝切片对125I-必利胆的吸收率，并提高了其从肝切片中的释放率。
