Davydovich O V
Farmakol Toksikol. 1984 Jan-Feb;47(1):101-4.
It has been shown in experiments on female rats that there are circadian and seasonal modulations in the liver reaction to bilignost administration. The most copious bile secretion was observed in the morning and evening hours in summer and in the evening hours in winter. The minimal liver sensitivity to bilignost was found in the summer group animals. It is suggested that rhythmic activity of the hypothalamohypophyseal-adrenal system underlies the changes in liver sensitivity to bilignost.
在对雌性大鼠的实验中发现，肝脏对必利肝灵给药的反应存在昼夜节律和季节性调节。夏季，胆汁分泌量最大的时候出现在早晨和傍晚；冬季则出现在傍晚。夏季组动物的肝脏对必利肝灵的敏感性最低。据推测，下丘脑 - 垂体 - 肾上腺系统的节律性活动是肝脏对必利肝灵敏感性变化的基础。
