[Pharmacokinetic characteristics of drugs in experimental splenectomy].

Pharmacokinetics of antipyrine, hexenal, phenylbutasone and caffeine was studied in experiments on splenectomized male rats. It was found that the half-life of all the drugs increased and plasma clearance decreased. Total protein binding assessed by using congo red decreased to a certain degree after splenectomy. The main factor modifying pharmacokinetics of drugs following splenectomy is believed to be depression of biotransformation processes in the liver.