高 L1CAM 表达预示子宫内膜癌患者预后不良：系统评价和荟萃分析。
High L1CAM expression predicts poor prognosis of patients with endometrial cancer: A systematic review and meta-analysis.
机构信息
Department of Gynecology and Obstetrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University.
Department of Gynecology, University Hospital, University of Electronic Science and Technology of China.
出版信息
Medicine (Baltimore). 2021 Apr 2;100(13):e25330. doi: 10.1097/MD.0000000000025330.
BACKGROUD
Previous studies have reported that the levels of L1 cell adhesion molecule (L1CAM) indicate poor prognosis of patients with various solid tumors. However, the prognostic significance of L1CAM in endometrial cancer has remained controversial. Herein, we conducted a systematic review and meta-analysis to evaluate the prognostic value of L1CAM in endometrial cancer.
METHODS
All studies related to the association between L1CAM expression and clinical characteristics of endometrial cancer were identified by searching the PubMed, MEDLINE, EMBASE, and Web of Science databases. Primary outcomes of the meta-analysis were the hazard ratios (HRs) for overall survival (OS) and disease-free survival (DFS). Secondary outcomes were odds ratios (ORs) for clinicopathological characteristics. Publication bias and sensitivity analysis were conducted to ensure reliability of the results.
RESULTS
Overall, 17 studies encompassing 7146 patients were eligible for the meta-analysis. Results showed L1CAM overexpression to be significantly associated with decreased overall survival (HR = 2.87, 95% CI; 1.81-4.55, P < .001) and disease-free survival (HR = 3.32, 95% CI; 1.99-5.55, P < .001) in patients with endometrial cancer. High L1CAM expression was also related to adverse clinicopathological characteristics.
CONCLUSION
This systematic review demonstrated that high L1CAM expression is correlated with poor survival outcomes and adverse clinicopathological parameters in patients with endometrial cancer.
背景
先前的研究报告称，L1 细胞黏附分子（L1CAM）的水平表明各种实体瘤患者的预后不良。然而，L1CAM 在子宫内膜癌中的预后意义仍存在争议。在此，我们进行了系统评价和荟萃分析，以评估 L1CAM 在子宫内膜癌中的预后价值。
方法
通过搜索 PubMed、MEDLINE、EMBASE 和 Web of Science 数据库，确定了所有与 L1CAM 表达与子宫内膜癌临床特征相关的研究。荟萃分析的主要结局是总生存率（OS）和无病生存率（DFS）的风险比（HRs）。次要结局是临床病理特征的比值比（ORs）。进行了发表偏倚和敏感性分析，以确保结果的可靠性。
结果
总体而言，有 17 项研究纳入了 7146 名患者，符合荟萃分析的条件。结果表明，L1CAM 过表达与子宫内膜癌患者的总生存率（HR=2.87，95%CI：1.81-4.55，P<0.001）和无病生存率（HR=3.32，95%CI：1.99-5.55，P<0.001）显著降低相关。高 L1CAM 表达也与不良的临床病理特征相关。
结论
本系统评价表明，L1CAM 高表达与子宫内膜癌患者的生存结局不良和不良临床病理参数相关。
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