Linden C H, Hall A H, Kulig K W, Rumack B H
J Toxicol Clin Toxicol. 1986;24(4):269-79. doi: 10.3109/15563658608992592.
Four patients with elevated serum boric acid levels after single, acute ingestions of 10 to 297 grams were reported to the Rocky Mountain Poison and Drug Center (RMPDC) between January 1983 and August 1985. Systemic effects were absent. In 1983-4, 364 cases of boric acid exposure were reported to the RMPDC with only one fatality from a probable chronic ingestion. Vomiting, nausea, diarrhea, and abdominal cramps were rather common. Systemic effects were notably absent in acute ingestions. Five of three hundred sixty-four patients had measured serum levels and were the only ones hospitalized. These observations suggest that significant poisoning is unlikely to result from a single, acute ingestion of boric acid. Serum boric acid levels appear to correlate poorly with clinical toxicity following acute ingestion.
1983年1月至1985年8月期间,有4名单次急性摄入10至297克硼酸后血清硼酸水平升高的患者被报告至落基山毒物与药物中心(RMPDC)。这些患者并无全身中毒症状。1983年至1984年期间,RMPDC共收到364例硼酸暴露报告,其中仅1例可能因长期摄入而死亡。呕吐、恶心、腹泻和腹部绞痛较为常见。急性摄入时明显没有全身中毒症状。364名患者中有5人检测了血清硼酸水平,且只有这5人住院治疗。这些观察结果表明,单次急性摄入硼酸不太可能导致严重中毒。急性摄入后,血清硼酸水平与临床毒性之间的相关性似乎较差。