Department of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan
Department of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
Anticancer Res. 2021 Mar;41(3):1365-1375. doi: 10.21873/anticanres.14894.
BACKGROUND/AIM: Progress in cancer treatment and diagnosis has made second cancer after medical radiation exposure a particular concern among childhood cancer survivors. Calorie restriction (CR) is a broadly effective cancer prevention strategy, although its effects on radiation-induced intestinal tumours are unclear. Here we examined the cancer-preventative efficacy of a CR diet at different starting ages on radiation induction of intestinal tumours in mice.
Male C3B6F1 Apc mice were irradiated with 0 or 2 Gy of X-rays at 2 weeks of age. After an interval of 2, 8 or 18 weeks, mice were fed with a non-CR (95 kcal/week/mouse) or CR (65 kcal/week/mouse) diet. Intestinal tumours were evaluated for number, size distribution and malignancy.
CR suppressed the size and progression of both spontaneous and radiation-induced intestinal tumours depending on age at starting of CR. CR diets were effective even administered to adult mice.
CR was effective for suppression of tumour progression, which was accelerated by radiation exposure. Use of CR might be a useful cancer-prevention strategy for radiation-induced tumours of the intestinal tract.
背景/目的：癌症治疗和诊断的进展使得接受过医学辐射暴露的二次癌症成为儿童癌症幸存者特别关注的问题。热量限制（CR）是一种广泛有效的癌症预防策略，尽管其对辐射诱导的肠道肿瘤的影响尚不清楚。在这里，我们研究了不同起始年龄的 CR 饮食对小鼠辐射诱导的肠道肿瘤的癌症预防效果。
雄性 C3B6F1 Apc 小鼠在 2 周龄时接受 0 或 2 Gy 的 X 射线照射。间隔 2、8 或 18 周后，小鼠喂食非 CR（95 kcal/周/只）或 CR（65 kcal/周/只）饮食。评估肠道肿瘤的数量、大小分布和恶性程度。
CR 抑制了自发和辐射诱导的肠道肿瘤的大小和进展，这取决于开始 CR 的年龄。即使在成年小鼠中给予 CR 饮食也有效。
CR 对肿瘤进展的抑制是有效的，而辐射暴露会加速肿瘤进展。CR 的使用可能是预防辐射诱导的肠道肿瘤的一种有用的癌症预防策略。
