一例由白萝卜通过IgE介导的速发型过敏反应引起的手部荨麻疹、唇部血管性水肿和口咽瘙痒病例。

A case of hand urticaria, lip angioedema, and oropharyngeal pruritus induced by Japanese radish through IgE-mediated immediate allergic reaction.

作者信息

Abe Sumiko, Ito Jun, Harada Sonoko, Sasano Hitoshi, Ueda Shoko, Sandhu Yuuki, Takeshige Tomohito, Katsura Yoko, Harada Norihiro, Takahashi Kazuhisa

机构信息

Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-8431, Japan.

Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Kanagawa, Japan.

出版信息

Allergy Asthma Clin Immunol. 2021 Mar 31;17(1):36. doi: 10.1186/s13223-021-00538-1.

DOI:10.1186/s13223-021-00538-1

PMID:33789748

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8010957/

Abstract

BACKGROUND

Although Japanese radish (Raphanus sativus L.) is a common Japanese ingredient, there are few reports of IgE-mediated immediate food allergy caused by Japanese radish.

CASE PRESENTATION

A 48-year-old woman developed urticarial lesions on her hands after grating Japanese radish and also developed lip edema and oral itching when she ate a salad composed of raw Japanese radishes. Skin prick testing was positive to extract of grated Japanese radish. Moreover, immunoblotting analysis showed IgE reactivity in the patient's serum to a single band at the 18 kDa in grated Japanese radish, suggesting that the heat-labile 18 kDa protein of raw Japanese radish may be a radish-specific antigen.

CONCLUSIONS

To the best of our knowledge, this is the first case report of a patient with hand urticaria, lip angioedema, and oropharyngeal pruritus to raw Japanese radish through IgE-mediated immediate allergic reaction.

摘要

背景

虽然日本萝卜（萝卜属萝卜种）是日本常见的食材，但由日本萝卜引起的IgE介导的速发型食物过敏报道较少。

病例报告

一名48岁女性在磨碎日本萝卜后手部出现荨麻疹皮损，食用由生日本萝卜组成的沙拉时还出现唇部水肿和口腔瘙痒。皮肤点刺试验对磨碎的日本萝卜提取物呈阳性。此外，免疫印迹分析显示患者血清中IgE与磨碎的日本萝卜中18 kDa处的单一条带发生反应，提示生日本萝卜中热不稳定的18 kDa蛋白可能是萝卜特异性抗原。