Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, 3004-504, Portugal
Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, 3004-504, Portugal.
J Neurosci. 2021 Mar 31;41(13):2796-2813. doi: 10.1523/JNEUROSCI.2251-20.2021.
Ubiquitin tagging sets protein fate. With a wide range of possible patterns and reversibility, ubiquitination can assume many shapes to meet specific demands of a particular cell across time and space. In neurons, unique cells with functionally distinct axons and dendrites harboring dynamic synapses, the ubiquitin code is exploited at the height of its power. Indeed, wide expression of ubiquitination and proteasome machinery at synapses, a diverse brain ubiquitome, and the existence of ubiquitin-related neurodevelopmental diseases support a fundamental role of ubiquitin signaling in the developing and mature brain. While special attention has been given to dendritic ubiquitin-dependent control, how axonal biology is governed by this small but versatile molecule has been considerably less discussed. Herein, we set out to explore the ubiquitin-mediated spatiotemporal control of an axon's lifetime: from its differentiation and growth through presynaptic formation, function, and pruning.
泛素化标记决定蛋白质命运。泛素化具有广泛的可能模式和可逆性，可以呈现出多种形状，以满足特定细胞在时间和空间上的特定需求。在神经元中，具有功能不同的轴突和树突的独特细胞，承载着动态的突触，泛素密码在其功能的巅峰时期得到了充分利用。事实上，突触处泛素化和蛋白酶体机制的广泛表达、丰富的大脑泛素组，以及与泛素相关的神经发育性疾病的存在，都支持泛素信号在发育和成熟大脑中的基本作用。虽然人们特别关注树突状泛素依赖性控制，但这种小而多功能的分子如何控制轴突生物学的问题还讨论得很少。在这里，我们着手探索泛素介导的轴突寿命的时空控制：从其分化和生长到突触前形成、功能和修剪。
