Department of Biology, University of Padua, Via U. Bassi 58B, 35121 Padua, Italy.
Department of Biology, University of Padua, Via U. Bassi 58B, 35121 Padua, Italy
Development. 2021 Mar 31;148(7):dev197384. doi: 10.1242/dev.197384.
Smooth muscle cells (SMCs) represent a major structural and functional component of many organs during embryonic development and adulthood. These cells are a crucial component of vertebrate structure and physiology, and an updated overview of the developmental and functional process of smooth muscle during organogenesis is desirable. Here, we describe the developmental origin of SMCs within different tissues by comparing their specification and differentiation with other organs, including the cardiovascular, respiratory and intestinal systems. We then discuss the instructive roles of smooth muscle in the development of such organs through signaling and mechanical feedback mechanisms. By understanding SMC development, we hope to advance therapeutic approaches related to tissue regeneration and other smooth muscle-related diseases.
平滑肌细胞（SMCs）是胚胎发育和成年期许多器官的主要结构和功能组成部分。这些细胞是脊椎动物结构和生理学的关键组成部分，因此需要对 SMC 在器官发生过程中的发育和功能过程进行更新概述。在这里，我们通过比较其在心血管、呼吸和肠道系统等其他器官中的特化和分化来描述不同组织中 SMC 的发育起源。然后，我们讨论了 SMC 通过信号和机械反馈机制在这些器官发育中的指导作用。通过了解 SMC 的发育，我们希望能够推进与组织再生和其他与平滑肌相关的疾病相关的治疗方法。
