School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin University, Bentley, Western Australia, Australia.
Curtin Health Innovation Research Institute (CHIRI), Faculty of Health Sciences, Curtin University, Bentley, Western Australia, Australia.
Postgrad Med J. 2022 Sep;98(1163):723-727. doi: 10.1136/postgradmedj-2021-139839. Epub 2021 Mar 31.
Cardiovascular disease (CVD) is one of the greatest disease burdens and takes the lives of many each year. There are many risk factors both modifiable and non-modifiable which contribute to the onset and progression of the disease. Trimethylamine N-oxide (TMAO) in recent years has been found to have a correlation with CVD onset. Those with increased levels of the metabolite have a markedly increased risk of future development of cardiometabolic disorders.This literature review aimed to critique past studies undertaken to find a consensus of the significance of the interrelationship between TMAO and cardiovascular risk. A definite link between TMAO levels and a CVD outcome was found. The majority of the literature stated the relationship with evidence; however, there is still some uncertainty as to why and how the correlation occurs. Further study needs to be done to further dissect and understand the relationship between TMAO and CVD risk.
心血管疾病（CVD）是最大的疾病负担之一，每年夺走许多人的生命。有许多可改变和不可改变的风险因素导致疾病的发生和发展。近年来，三甲基胺 N-氧化物（TMAO）被发现与 CVD 的发病有关。那些代谢物水平升高的人，未来发生心脏代谢紊乱的风险明显增加。本文献综述旨在对过去的研究进行评估，以找到 TMAO 与心血管风险之间相互关系的共识。已经发现 TMAO 水平与 CVD 结果之间存在明确的联系。大多数文献都说明了这种关系的证据；然而，为什么以及如何发生这种相关性仍然存在一些不确定性。需要进一步研究以进一步分析和理解 TMAO 与 CVD 风险之间的关系。
