Infectious Diseases Surveillance Center, National Institute of Infectious Diseases, Japan.
Fukuda Hospital, Japan.
Jpn J Infect Dis. 2021 Nov 22;74(6):511-516. doi: 10.7883/yoken.JJID.2020.489. Epub 2021 Mar 31.
Neonatal pertussis can potentially cause severe complications and even death. Mothers have been most frequently identified as the source of neonatal pertussis. Approximately a dozen countries have implemented pertussis vaccination programs for pregnant women to protect neonates; however, in Japan, this has not been implemented. The aim of this questionnaire-based study was to ascertain the willingness of women to be vaccinated during pregnancy and the factors associated with willingness. The subjects were 977 pregnant women who visited either of the two selected hospitals for maternity health checks. Most of the women were in their first pregnancy (96%), and approximately half of them considered a physician to be the most reliable source of information about vaccination (481/977, 49%). "Willingness to receive pertussis vaccination" was significantly associated with the factors "no fear of receiving vaccination" (odds ratio [OR] = 3.10, 95% confidence interval [CI]: 2.21-4.34), "necessary to prevent pertussis" (OR = 8.70, 95% CI: 6.17-12.28), "effective in pregnancy" (OR = 5.46, 95% CI: 3.94-7.56), and "no concern about the side effects after vaccination" (OR = 3.03, 95% CI: 1.66-5.55). Pregnant women are likely to consider vaccination if they have a good understanding of the disease and its outcomes. Physicians are well positioned to improve knowledge and attitudes toward pertussis vaccination during pregnancy.
新生儿百日咳可能会导致严重并发症，甚至死亡。母亲是新生儿百日咳的最常见传染源。约有十几个国家已经为孕妇实施了百日咳疫苗接种计划，以保护新生儿；然而，日本尚未实施。本基于问卷的研究旨在确定女性在怀孕期间接种疫苗的意愿及其相关因素。研究对象为 977 名在选定的两家医院进行母婴健康检查的孕妇。大多数女性处于首次怀孕（96%），其中约一半认为医生是疫苗接种相关信息的最可靠来源（481/977，49%）。“是否愿意接种百日咳疫苗”与“不担心接种疫苗”（比值比[OR] = 3.10，95%置信区间[CI]：2.21-4.34）、“预防百日咳有必要”（OR = 8.70，95% CI：6.17-12.28）、“对孕期有效”（OR = 5.46，95% CI：3.94-7.56）和“不担心接种疫苗后的副作用”（OR = 3.03，95% CI：1.66-5.55）显著相关。如果孕妇对疾病及其后果有很好的了解，她们可能会考虑接种疫苗。医生非常适合提高对怀孕期间百日咳疫苗接种的知识和态度。
