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通过使用纳米颗粒递药系统增强癌症免疫治疗目标。

Enhancing Cancer Immunotherapy Treatment Goals by Using Nanoparticle Delivery System.

机构信息

Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, People's Republic of China.

Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, 646000, Sichuan, People's Republic of China.

出版信息

Int J Nanomedicine. 2021 Mar 25;16:2389-2404. doi: 10.2147/IJN.S295300. eCollection 2021.

Abstract

Recently, there has been an incredible increase in research about the abnormal growth of cells (neoplasm), focusing on the management, treatment and preventing reoccurrence. It has been understood that the natural defense system, composed of a variety of immune defensive cells, does not just limit its function in eliminating neoplastic cells, but also controls the growth and spread of tumor cells of different kinds to other parts of the body. Cancer immunotherapy, is a cancer treatment plan that educates the body's defensive system to forestall, control, and eliminate tumor cells. The effectiveness of immunotherapy is achieved, to its highest efficacy, by the use of nanoparticles (NPs) for precise and timely delivery of immunotherapies to specific targeted neoplasms, with less or no harm to the healthy cells. Immunotherapies have been affirmed in clinical trials as a cancer regimen for various types of cancers, the side effects resulting from imprecise and non-targeted conveyance is well managed with the use of nanoparticles. Nonetheless, we will concentrate on enhancing cancer immunotherapy approaches by the use of nanoparticles for the productivity of antitumor immunity. Nanoparticles will be presented and utilized as an objective immunotherapy delivery system for high exactness and are thus a promising methodology for cancer treatment.

摘要

最近,关于细胞异常生长(肿瘤)的研究呈爆炸式增长,研究重点主要集中在管理、治疗和预防复发方面。人们已经了解到,由多种免疫防御细胞组成的自然防御系统不仅局限于消除肿瘤细胞的功能,还控制着不同类型的肿瘤细胞向身体其他部位的生长和扩散。癌症免疫疗法是一种癌症治疗方案,旨在教育身体的防御系统来预防、控制和消除肿瘤细胞。免疫疗法的有效性通过使用纳米颗粒(NPs)来实现,这些纳米颗粒可以精确和及时地将免疫疗法递送到特定的靶肿瘤,对健康细胞的伤害更小或没有。免疫疗法在临床试验中已被确认为治疗各种类型癌症的方案,使用纳米颗粒可以很好地控制因非精确和非靶向传递而产生的副作用。然而,我们将专注于通过使用纳米颗粒增强癌症免疫疗法方法,以提高抗肿瘤免疫的效果。纳米颗粒将被用作一种客观的免疫疗法递送系统,具有高精度,因此是一种有前途的癌症治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8b42/8007559/8e2ec01d6720/IJN-16-2389-g0001.jpg

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