Xu Jingjing, Tao Chunwen, Mao Xinjie, Lu Xin, Bao Jinhua, Drobe Björn, Chen Hao
School of Ophthalmology and Optometry, Affiliated Eye Hospital, State Key Laboratory of Ophthalmology, Optometry and Vision Science, Wenzhou Medical University, Wenzhou, China.
WEIRC, Wenzhou Medical University-Essilor International Research Center, Wenzhou, China.
Front Neurosci. 2021 Mar 12;15:630844. doi: 10.3389/fnins.2021.630844. eCollection 2021.
To investigate changes in blur detection sensitivity in children using orthokeratology (Ortho-K) and explore the relationships between blur detection thresholds (BDTs) and aberrations and accommodative function.
Thirty-two children aged 8-14 years old who underwent Ortho-K treatment participated in and completed this study. Their BDTs, aberrations, and accommodative responses (ARs) were measured before and after a month of Ortho-K treatment. A two forced-choice double-staircase procedure with varying extents of blur in three images (Tumbling Es, Lena, and Street View) was used to measure the BDTs. The participants were required to judge whether the images looked blurry. The BDT of each of the images (BDT_Es, BDT_Lena, and BDT_Street) was the average value of the last three reversals. The accommodative lag was quantified by the difference between the AR and the accommodative demand (AD). Changes in the BDTs, aberrations, and accommodative lags and their relationships were analyzed.
After a month of wearing Ortho-K lenses, the children's BDT_Es and BDT_Lena values decreased, the aberrations increased significantly (for all, ≤0.050), and the accommodative lag decreased to a certain extent [T(31) = 2.029, = 0.051]. Before Ortho-K treatment, higher-order aberrations (HOAs) were related to BDT_Lena ( = 0.463, = 0.008) and the accommodative lag was related to BDT_Es ( = -0.356, = -0.046). After one month, no significant correlations were found between the BDTs and aberrations or accommodative lags, as well as between the variations of them (for all, ≥ 0.069).
Ortho-K treatment increased the children's level of blur detection sensitivity, which may have contributed to their good visual acuity.
研究使用角膜塑形术（Ortho-K）的儿童的模糊检测灵敏度变化，并探讨模糊检测阈值（BDT）与像差及调节功能之间的关系。
32名接受Ortho-K治疗的8至14岁儿童参与并完成了本研究。在Ortho-K治疗前和治疗一个月后测量他们的BDT、像差和调节反应（AR）。采用双选双阶梯程序，在三张图像（翻滚的E、莉娜和街景）中设置不同程度的模糊，来测量BDT。参与者被要求判断图像是否看起来模糊。每张图像的BDT（BDT_Es、BDT_Lena和BDT_Street）是最后三次反转的平均值。调节滞后通过AR与调节需求（AD）之间的差异来量化。分析BDT、像差和调节滞后的变化及其关系。
佩戴Ortho-K镜片一个月后，儿童的BDT_Es和BDT_Lena值降低，像差显著增加（所有P≤0.050），调节滞后在一定程度上降低[T(31)=2.029，P=0.051]。在Ortho-K治疗前，高阶像差（HOAs）与BDT_Lena相关（P=0.463，P=0.008），调节滞后与BDT_Es相关（P=-0.356，P=-0.046）。一个月后，BDT与像差或调节滞后之间以及它们的变化之间均未发现显著相关性（所有P≥0.069）。
Ortho-K治疗提高了儿童的模糊检测灵敏度水平，这可能有助于他们获得良好的视力。
