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皮下注射醋酸格拉替雷后发生的药物性皮肤栓塞

Embolia Cutis Medicamentosa after Subcutaneous Injection with Glatiramer Acetate.

作者信息

Vlahova Lyubomira, Kretschmer Lutz, Schön Michael P, Mössner Rotraut

机构信息

Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany.

出版信息

Case Rep Dermatol. 2021 Feb 16;13(1):114-120. doi: 10.1159/000510017. eCollection 2021 Jan-Apr.

DOI:10.1159/000510017
PMID:33790754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7989669/
Abstract

Embolia cutis medicamentosa (ECM) is a rare and unpredictable injection site reaction, occurring after intramuscular, subcutaneous, and even after intraarticular injection of various drugs. We report a very rare case of necrotizing ECM after injection of glatiramer acetate for multiple sclerosis, include a photo documentation over the entire disease course, and discuss hypotheses as to etiology and treatment.

摘要

药物性皮肤栓塞（ECM）是一种罕见且不可预测的注射部位反应，发生于肌肉内、皮下甚至关节内注射各种药物之后。我们报告了一例非常罕见的在注射醋酸格拉替雷治疗多发性硬化后发生的坏死性ECM病例，包括整个病程的照片记录，并讨论了病因和治疗的假说。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab4f/7989669/b401ba42933a/cde-0013-0114-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab4f/7989669/c37b30e45058/cde-0013-0114-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab4f/7989669/467aaf024933/cde-0013-0114-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab4f/7989669/b401ba42933a/cde-0013-0114-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab4f/7989669/c37b30e45058/cde-0013-0114-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab4f/7989669/467aaf024933/cde-0013-0114-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab4f/7989669/b401ba42933a/cde-0013-0114-g03.jpg

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引用本文的文献

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Nicolau syndrome following glatiramer acetate for multiple sclerosis: Case and review of reports.尼科劳综合征继发于多发性硬化症的醋酸格拉替雷治疗：病例报告及文献复习。
Ann Clin Transl Neurol. 2024 Apr;11(4):1080-1085. doi: 10.1002/acn3.52044. Epub 2024 Mar 14.
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Adverse side effects of Glatiramer acetate and Interferon beta-1a in patients with multiple sclerosis: A systematic review of case reports.醋酸格拉替雷和干扰素β-1a治疗多发性硬化症患者的不良副作用：病例报告的系统评价
Curr J Neurol. 2023 Apr 4;22(2):115-136. doi: 10.18502/cjn.v22i2.13340.

本文引用的文献

1
[Suprapubic Nicolau syndrome following subcutaneous injection of glatiramer acetate].皮下注射醋酸格拉替雷后发生耻骨上区尼科劳综合征
Ann Dermatol Venereol. 2018 Nov;145(11):671-675. doi: 10.1016/j.annder.2018.04.012. Epub 2018 Sep 11.
2
Nicolau Syndrome (Embolia Cutis Medicamentosa): A Rare and Poorly Recognized Iatrogenic Cause of Cutaneous Thrombotic Vasculopathy.尼科劳综合征（药物性皮肤栓塞）：一种罕见且认识不足的医源性皮肤血栓性血管病病因。
Am J Dermatopathol. 2018 Mar;40(3):212-215. doi: 10.1097/DAD.0000000000000972.
3
Two Cases of Nicolau Syndrome Associated with Glatiramer Acetate.
两例与醋酸格拉替雷相关的尼科劳综合征
Int J MS Care. 2017 May-Jun;19(3):148-150. doi: 10.7224/1537-2073.2016-038.
4
Efficacy and safety of a three-times-weekly dosing regimen of glatiramer acetate in relapsing-remitting multiple sclerosis patients: 3-year results of the Glatiramer Acetate Low-Frequency Administration open-label extension study.在复发缓解型多发性硬化症患者中，每周三次给予醋酸格拉替雷的疗效和安全性：醋酸格拉替雷低频率给药开放性扩展研究的 3 年结果。
Mult Scler. 2017 May;23(6):818-829. doi: 10.1177/1352458516664033. Epub 2016 Aug 8.
5
Recurrent Nicolau syndrome associated with subcutaneous glatiramer acetate injection--a case report.与皮下注射醋酸格拉替雷相关的复发性尼科劳综合征——一例报告
BMC Neurol. 2015 Dec 2;15:249. doi: 10.1186/s12883-015-0504-0.
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GLACIER: An open-label, randomized, multicenter study to assess the safety and tolerability of glatiramer acetate 40 mg three-times weekly versus 20 mg daily in patients with relapsing-remitting multiple sclerosis.GLACIER：一项开放标签、随机、多中心研究，旨在评估复发缓解型多发性硬化症患者中，每周三次40毫克醋酸格拉替雷与每日20毫克醋酸格拉替雷的安全性和耐受性。
Mult Scler Relat Disord. 2015 Jul;4(4):370-6. doi: 10.1016/j.msard.2015.06.005. Epub 2015 Jun 14.
7
Significance of ultrasound examination of skin and subcutaneous tissue in secondary lower extremity lymphedema.超声检查在继发性下肢淋巴水肿中对皮肤及皮下组织的意义
Ann Vasc Dis. 2013;6(2):180-8. doi: 10.3400/avd.oa.12.00102. Epub 2013 May 10.
8
Three times weekly glatiramer acetate in relapsing-remitting multiple sclerosis.每周三次用醋酸格拉替雷治疗复发缓解型多发性硬化。
Ann Neurol. 2013 Jun;73(6):705-13. doi: 10.1002/ana.23938. Epub 2013 Jun 28.
9
Nicolau syndrome after intramuscular injection: 3 cases.肌肉注射后发生的尼科劳综合征：3例报告
Arch Plast Surg. 2012 May;39(3):249-52. doi: 10.5999/aps.2012.39.3.249. Epub 2012 May 10.
10
[Embolia cutis medicamentosa (Nicolau syndrome) after glatiramer acetate injection].醋酸格拉替雷注射后发生药物性皮肤栓塞（尼古劳综合征）
Actas Dermosifiliogr. 2011 Nov;102(9):742-4. doi: 10.1016/j.ad.2010.12.018. Epub 2011 Jul 8.