皮下注射醋酸格拉替雷后发生的药物性皮肤栓塞

Vlahova Lyubomira, Kretschmer Lutz, Schön Michael P, Mössner Rotraut

Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany.

Case Rep Dermatol. 2021 Feb 16;13(1):114-120. doi: 10.1159/000510017. eCollection 2021 Jan-Apr.

Embolia cutis medicamentosa (ECM) is a rare and unpredictable injection site reaction, occurring after intramuscular, subcutaneous, and even after intraarticular injection of various drugs. We report a very rare case of necrotizing ECM after injection of glatiramer acetate for multiple sclerosis, include a photo documentation over the entire disease course, and discuss hypotheses as to etiology and treatment.

药物性皮肤栓塞（ECM）是一种罕见且不可预测的注射部位反应，发生于肌肉内、皮下甚至关节内注射各种药物之后。我们报告了一例非常罕见的在注射醋酸格拉替雷治疗多发性硬化后发生的坏死性ECM病例，包括整个病程的照片记录，并讨论了病因和治疗的假说。