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肌肉注射后发生的尼科劳综合征：3例报告

Nicolau syndrome after intramuscular injection: 3 cases.

作者信息

Kim Seok-Kwun, Kim Tae-Heon, Lee Keun-Cheol

机构信息

Department of Plastic and Reconstructive Surgery, Dong-A University College of Medicine, Busan, Korea.

出版信息

Arch Plast Surg. 2012 May;39(3):249-52. doi: 10.5999/aps.2012.39.3.249. Epub 2012 May 10.

DOI:10.5999/aps.2012.39.3.249
PMID:22783535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3385328/
Abstract

Nicolau syndrome is a rare complication of intramuscular injection consisting of ischemic necrosis of skin, soft tissue, and muscular tissue that arises locoregionally. The characteristic pattern is pain around the injection site, developing into erythema, a livedoid dermatitis patch, and necrosis of the skin, subcutaneous fat, and muscle tissue. Three patients were injected with drugs (diclofenac sodium, ketoprofen, meperidine) for pain relief. Three patients complained of pain, and a skin lesion was observed, after which necrosis developed on their buttocks. Each patient underwent debridement and coverage. The wound healed uneventfully. We report three cases of Nicolau syndrome in the buttocks following diclofenac intramuscular injection.

摘要

尼科劳综合征是肌肉注射的一种罕见并发症，表现为局部出现皮肤、软组织和肌肉组织的缺血性坏死。其特征性表现为注射部位周围疼痛，继而发展为红斑、类紫癜样皮炎斑块，以及皮肤、皮下脂肪和肌肉组织坏死。3例患者因疼痛接受了药物（双氯芬酸钠、酮洛芬、哌替啶）注射。3例患者均主诉疼痛，并观察到皮肤病变，随后其臀部出现坏死。每位患者均接受了清创和创面覆盖处理。伤口顺利愈合。我们报告3例双氯芬酸肌肉注射后臀部发生尼科劳综合征的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84f0/3385328/4dc4433a1f8e/aps-39-249-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84f0/3385328/9945a2de4393/aps-39-249-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84f0/3385328/b14e8ac73453/aps-39-249-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84f0/3385328/1350aa3f19ae/aps-39-249-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84f0/3385328/7f7c8d8d3630/aps-39-249-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84f0/3385328/80b595a8ba6f/aps-39-249-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84f0/3385328/a8012ed70a28/aps-39-249-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84f0/3385328/4dc4433a1f8e/aps-39-249-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84f0/3385328/9945a2de4393/aps-39-249-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84f0/3385328/b14e8ac73453/aps-39-249-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84f0/3385328/1350aa3f19ae/aps-39-249-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84f0/3385328/7f7c8d8d3630/aps-39-249-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84f0/3385328/80b595a8ba6f/aps-39-249-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84f0/3385328/a8012ed70a28/aps-39-249-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84f0/3385328/4dc4433a1f8e/aps-39-249-g007.jpg

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本文引用的文献

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Nicolau syndrome caused by piroxicam.
Int J Dermatol. 2005 Dec;44(12):1069-70. doi: 10.1111/j.1365-4632.2004.02534.x.
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Nicolau's syndrome after local glucocorticoid injection.
Joint Bone Spine. 2003 Sep;70(5):390-2. doi: 10.1016/s1297-319x(03)00137-4.
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Skin necrosis following injection of non-steroidal anti-inflammatory drug.
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Five cases of livedo-like dermatitis (Nicolau's syndrome) due to bismuth salts and various other non-steroidal anti-inflammatory drugs.五例由铋盐及其他多种非甾体抗炎药引起的类青斑样皮炎（尼科劳综合征）。
一种针对尼科劳综合征的基本手术算法方法。
J Cutan Aesthet Surg. 2020 Apr-Jun;13(2):154-159. doi: 10.4103/JCAS.JCAS_139_19.
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A misplaced intramuscular injection and limb-threatening ischemia.一次误行的肌肉注射与危及肢体的缺血。
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Nicolau syndrome after lumbar puncture: A case report in a 22-month-old girl.腰椎穿刺后尼科劳综合征：一名22个月大女童的病例报告。
JAAD Case Rep. 2017 Jan 10;3(1):33-35. doi: 10.1016/j.jdcr.2016.09.004. eCollection 2017 Jan.
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Nicolau Syndrome due to Penicillin Injection: A Report of 3 Cases without Long-Term Complication.青霉素注射所致尼科劳综合征：3例无长期并发症报告
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An avoidable adverse drug reaction: Nicolau syndrome.一种可避免的药物不良反应：尼科洛综合征。
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Claudication Due to Sciatic Nerve Palsy Following Nicolau Syndrome: A Case Report.尼科劳综合征后坐骨神经麻痹所致跛行：一例报告
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Nicolau syndrome after intramuscular injection of non-steroidal anti-inflammatory drugs (NSAID).肌肉注射非甾体抗炎药（NSAID）后发生的尼科劳综合征。
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Crushed and injected buprenorphine tablets: characteristics of princeps and generic solutions.碾碎并注射丁丙诺啡片：原研药与仿制药溶液的特性
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Livedoid skin necrosis (Nicolau syndrome) due to triple vaccine (DTP) injection.三联疫苗（百白破疫苗）注射导致的类脂质渐进性坏死（尼科劳综合征）
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6
What syndrome is this? Nicolau syndrome.这是什么综合征？尼科劳综合征。
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