Youn Gun Min, Cheema Karan S, Young Peter A, Bae Gordon H
Department of Dermatology, Stanford University School of Medicine, Palo Alto, USA.
School of Public Health, Brown University, Providence, USA.
Cureus. 2024 Feb 6;16(2):e53746. doi: 10.7759/cureus.53746. eCollection 2024 Feb.
Nicolau syndrome is a rare adverse reaction that can occur in the setting of intramuscular, intravenous, and subcutaneous injections. Proper diagnosis and management are critical to avoid complications including abscesses, muscular atrophy, and necrotizing fasciitis. Here, we report a 55-year-old female with multiple sclerosis who presented to our clinic following a subcutaneous injection of 40mg of glatiramer. She immediately noted a sharp pain and erythema, which developed into a purple discoloration, became purulent, and eventually necrosed. The patient's wound was debrided, and she was advised to clean the wound with soap and water, apply topical mupirocin, and change dressings twice daily. She continued to receive appropriate follow-up care with weekly to bi-weekly debridement with excellent resolution.
尼科劳综合征是一种罕见的不良反应，可发生于肌内注射、静脉注射和皮下注射的情况下。正确的诊断和处理对于避免包括脓肿、肌肉萎缩和坏死性筋膜炎在内的并发症至关重要。在此，我们报告一名55岁的多发性硬化症女性患者，她在皮下注射40mg格拉替雷后前来我们诊所就诊。她立即感到剧痛和红斑，随后发展为紫色变色，出现化脓，最终坏死。患者的伤口进行了清创处理，并建议她用肥皂和水清洗伤口，局部应用莫匹罗星，每天更换两次敷料。她继续接受适当的随访护理，每周至每两周进行一次清创，恢复情况良好。
