Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Core Research Laboratory, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Front Immunol. 2021 Mar 15;12:594858. doi: 10.3389/fimmu.2021.594858. eCollection 2021.
The skin is a complex organ that faces the external environment and participates in the innate immune system. Skin immune homeostasis is necessary to defend against external microorganisms and to recover from stress to the skin. This homeostasis depends on interactions among a variety of cells, cytokines, and the complement system. Collectins belong to the lectin pathway of the complement system, and have various roles in innate immune responses. Mannose-binding lectin (MBL), collectin kidney 1, and liver (CL-K1, CL-L1) activate the lectin pathway, while all have multiple functions, including recognition of pathogens, opsonization of phagocytosis, and modulation of cytokine-mediated inflammatory responses. Certain collectins are localized in the skin, and their expressions change during skin diseases. In this review, we summarize important advances in our understanding of how MBL, surfactant proteins A and D, CL-L1, and CL-K1 function in skin immune homeostasis. Based on the potential roles of collectins in skin diseases, we suggest therapeutic strategies for skin diseases through the targeting of collectins and relevant regulators.
皮肤是一种复杂的器官，它与外界环境接触，并参与先天免疫系统。皮肤免疫稳态对于抵御外来微生物和从皮肤应激中恢复是必要的。这种内稳依赖于各种细胞、细胞因子和补体系统之间的相互作用。凝集素属于补体系统的凝集素途径，在先天免疫反应中具有多种功能。甘露聚糖结合凝集素 (MBL)、肾 1 型和肝 (CL-K1、CL-L1) 凝集素激活凝集素途径，而它们都具有多种功能，包括识别病原体、吞噬作用的调理作用以及调节细胞因子介导的炎症反应。某些凝集素定位于皮肤，其表达在皮肤病中发生变化。在这篇综述中，我们总结了我们对 MBL、表面活性剂蛋白 A 和 D、CL-L1 和 CL-K1 在皮肤免疫内稳中的作用的理解的重要进展。基于凝集素在皮肤病中的潜在作用，我们通过针对凝集素和相关调节剂提出了皮肤病的治疗策略。
