Kasai Mari, Sugawara Tomohiro, Takada Junko, Kumai Keiichi, Nakamura Kei, Meguro Kenichi
Geriatric Behavioral Neurology Project, New Industry Creation Hatchery Center, Tohoku University, Sendai, Japan.
Cyclotron Radioisotope Center, Tohoku University, Sendai, Japan.
Dement Geriatr Cogn Dis Extra. 2021 Feb 18;11(1):45-50. doi: 10.1159/000514324. eCollection 2021 Jan-Apr.
To assess cognitive impairment, self-awareness is an important issue. The Ascertain Dementia 8 questionnaire (AD8) is a brief observation checklist for detecting mild cognitive impairment (MCI) and dementia. After analyzing the reliability and validity of a self-reported Japanese version of the AD8 (AD8-J), we compared self- and informant-reported versions of the AD8-J.
A total of 93 community residents aged 75 years or older living in Wakuya, Northern Japan, agreed to participate in this study; 35 were rated as Clinical Dementia Rating (CDR) 0 (healthy), 46 as CDR 0.5 (defined herein as MCI), and 12 as CDR 1 or above (dementia, confirmed by the DSM-IV). We examined the reliability and validity using a receiver operating characteristic (ROC) curve. We analyzed the differences between self-reported and informant-reported AD8-J using a repeated measures ANOVA.
The self-reported AD8-J showed a satisfactory reliability (i.e., Cronbach coefficient, α = 0.71; Guttman split half method coefficient = 0.60). For CDR 0 vs. CDR 0.5 or above, the area under the ROC curve was 0.74 and the cutoff score was 1/2, with a sensitivity of 70.7% and a specificity of 65.7%. Analysis of the subscores of AD8 suggested that, from the early stage of dementia, the subjects showed a subjective decline in memory and interest in hobbies/activities, as well as problems with judgment.
It is suggested that the self-reported AD8-J was effective in detecting MCI and dementia. We could use it for detecting MCI and dementia, including in those living alone, in the primary health checkup.
为评估认知障碍，自我认知是一个重要问题。痴呆筛查8项问卷（AD8）是一种用于检测轻度认知障碍（MCI）和痴呆的简短观察检查表。在分析了自我报告的日语版AD8（AD8-J）的信效度后，我们比较了AD8-J的自我报告版和知情者报告版。
日本北部若叶地区93名75岁及以上的社区居民同意参与本研究；35人临床痴呆评定量表（CDR）评分为0（健康），46人评分为0.5（本研究中定义为MCI），12人评分为1及以上（痴呆，经DSM-IV确诊）。我们使用受试者工作特征（ROC）曲线检验信效度。我们采用重复测量方差分析来分析自我报告和知情者报告的AD8-J之间的差异。
自我报告的AD8-J显示出令人满意的信度（即Cronbach系数，α = 0.71；古特曼折半法系数 = 0.60）。对于CDR 0与CDR 0.5及以上，ROC曲线下面积为0.74，临界值为1/2，灵敏度为70.7%，特异度为65.7%。AD8子分数分析表明，从痴呆早期开始，受试者就表现出记忆力主观下降、对爱好/活动的兴趣下降以及判断力问题。
自我报告的AD8-J在检测MCI和痴呆方面似乎是有效的。我们可以将其用于在初级健康检查中检测MCI和痴呆，包括独居者。
