Hida Richard Yudi, Silva Cely Barreto, Romero-Kusabara Ivana Lopes, Mimica Lycia Mara Jenne
Department of Ophthalmology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
Department of Ophthalmology, Keio University- School of Medicine, Tokyo, Japan.
BMJ Open Ophthalmol. 2021 Mar 17;6(1):e000591. doi: 10.1136/bmjophth-2020-000591. eCollection 2021.
To compare the antimicrobial effect in vitro of a short-chain cyanoacrylate with a long-chain cyanoacrylate (Dermabond, Ethicon, Johnson and Johnson, USA) against bacterial strains.
The following bacterial strains were analysed: , , and . For each microorganism, standardised sterile discs (6 mm) containing 10 µL of ethyl-cyanoacrylate and 2-octyl cyanoacrylate were applied to the plate. All plates received a blank filter-paper disc with no adhesive (control). All plates were incubated for 24 hours, after which the bacterial inhibitory halos, if present, were measured in millimetres in its greater length.
Inhibitory halos were observed for both adhesives for . Inhibition halos were observed only for ethyl-cyanoacrylate for and . No inhibition halo was observed for in any sample. The relationship between the total size of the inhibition halos and the diameter of the paper filter for was statistically significant compared with 2-octyl cyanoacrylate.
Data shown conclude that ethyl-cyanoacrylate showed in vitro bacteriostatic activity for , and . 2-Octyl cyanoacrylate showed in vitro lower bacteriostatic activity only against when compared with ethyl-cyanoacrylate. No in vitro bactericidal activity of ethyl-cyanoacrylate or 2-octyl cyanoacrylate was observed.
比较一种短链氰基丙烯酸酯与一种长链氰基丙烯酸酯（美国强生公司Ethicon生产的皮肤黏合剂）对细菌菌株的体外抗菌效果。
分析了以下细菌菌株：[具体菌株名称缺失]、[具体菌株名称缺失]、[具体菌株名称缺失]和[具体菌株名称缺失]。对于每种微生物，将含有10微升乙基氰基丙烯酸酯和2-辛基氰基丙烯酸酯的标准化无菌圆盘（6毫米）应用于培养皿。所有培养皿均接受一个不含粘合剂的空白滤纸圆盘（对照）。所有培养皿均孵育24小时，之后测量细菌抑制晕圈（若存在），以毫米为单位测量其最大长度。
两种粘合剂对[具体菌株名称缺失]均观察到抑制晕圈。仅乙基氰基丙烯酸酯对[具体菌株名称缺失]和[具体菌株名称缺失]观察到抑制晕圈。在任何样品中对[具体菌株名称缺失]均未观察到抑制晕圈。与2-辛基氰基丙烯酸酯相比，[具体菌株名称缺失]的抑制晕圈总大小与滤纸直径之间的关系具有统计学意义。
所示数据表明，乙基氰基丙烯酸酯对[具体菌株名称缺失]、[具体菌株名称缺失]和[具体菌株名称缺失]显示出体外抑菌活性。与乙基氰基丙烯酸酯相比，2-辛基氰基丙烯酸酯仅对[具体菌株名称缺失]显示出较低的体外抑菌活性。未观察到乙基氰基丙烯酸酯或2-辛基氰基丙烯酸酯的体外杀菌活性。
