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大流行期间潜在的SARS-CoV-2感染背景下非小细胞肺癌的治疗前景

Perspective on the treatment of non-small cell lung cancer in the context of potential SARS-CoV-2 infection during the pandemic.

作者信息

Theodoropoulos George, Albanis Katerina, Wangpaichitr Medhi

机构信息

Department of Veterans Affairs, Miami VA Healthcare System, Research Service, Miami, FL.

Department of Surgery, Cardiothoracic Surgery, Miller School of Medicine, University of Miami, Miami, FL.

出版信息

J Curr Sci Technol. 2021 Jan;11(1). doi: 10.14456/jcst.2021.15.

DOI:10.14456/jcst.2021.15
PMID:33791600
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8008947/
Abstract

SARS-CoV-2 infections are rising at an alarming rate and various aspects of this pandemic must be quickly and adequately addressed in order to enhance effective healthcare delivery and protect at risk populations such as cancer patients. Preventing Covid-19 infection must be a top system wide priority to avoid mortality, and considerable financial and disease burden. Most cancer patients, and in particular those with tumors resistant to chemotherapy are particularly vulnerable to infection. In this review, we connect potential viral infection of patients with lung tumors that have somewhat quiescence the immune response in the tumor microenvironment and categorize target molecules in metabolism that may be used to identify at risk patients leading to more effective treatment regimens; keeping continuity of therapy and disease prevention during a very tumultuous period of time surrounding the pandemic.

摘要

严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染正在以惊人的速度上升,必须迅速且充分地应对这场大流行的各个方面,以加强有效的医疗服务,并保护癌症患者等高危人群。预防新型冠状病毒肺炎(Covid-19)感染必须成为全系统的首要优先事项,以避免死亡以及巨大的经济和疾病负担。大多数癌症患者,尤其是那些对化疗耐药的肿瘤患者,特别容易受到感染。在本综述中,我们将肺部肿瘤患者潜在的病毒感染与肿瘤微环境中免疫反应有所静止的情况联系起来,并对代谢中的靶分子进行分类,这些分子可用于识别高危患者,从而制定更有效的治疗方案;在围绕大流行的非常动荡时期保持治疗的连续性和疾病预防。

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