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鉴定GINS1作为感染COVID-19的癌症患者的治疗靶点：一种生物信息学和系统生物学方法。

Identification of GINS1 as a therapeutic target in the cancer patients infected with COVID-19: a bioinformatics and system biology approach.

作者信息

Hu Changpeng, Dai Yue, Zhou Huyue, Zhang Jing, Xie Dandan, Xu Rufu, Yang Mengmeng, Zhang Rong

机构信息

Department of Pharmacy, The Second Affiliated Hospital of Army Medical University, 83 Xinqiao Road, 400037, Chongqing, China.

出版信息

Hereditas. 2022 Dec 1;159(1):45. doi: 10.1186/s41065-022-00258-5.

DOI:10.1186/s41065-022-00258-5
PMID:36451247
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9713126/
Abstract

BACKGROUND

Coronavirus disease 2019 (COVID-19) caused a series of biological changes in cancer patients which have rendered the original treatment ineffective and increased the difficulty of clinical treatment. However, the clinical treatment for cancer patients infected with COVID-19 is currently unavailable. Since bioinformatics is an effective method to understand undiscovered biological functions, pharmacological targets, and therapeutic mechanisms. The aim of this study was to investigate the influence of COVID-19 infection in cancer patients and to search the potential treatments.

METHODS

Firstly, we obtained the COVID-19-associated genes from seven databases and analyzed the cancer pathogenic genes from Gene Expression Omnibus (GEO) databases, respectively. The Cancer/COVID-19-associated genes were shown by Venn analyses. Moreover, we demonstrated the signaling pathways and biological functions of pathogenic genes in Cancer/COVID-19.

RESULTS

We identified that Go-Ichi-Ni-San complex subunit 1 (GINS1) is the potential therapeutic target in Cancer/COVID-19 by GEPIA. The high expression of GINS1 was not only promoting the development of cancers but also affecting their prognosis. Furthermore, eight potential compounds of Cancer/COVID-19 were identified from CMap and molecular docking analysis.

CONCLUSION

We revealed the GINS1 is a potential therapeutic target in cancer patients infected with COVID-19 for the first time, as COVID-19 will be a severe and prolonged pandemic. However, the findings have not been verified actually cancer patients infected with COVID-19, and further studies are needed to demonstrate the functions of GINS1 and the clinical treatment of the compounds.

摘要

背景

2019冠状病毒病（COVID-19）在癌症患者中引发了一系列生物学变化，这些变化使原有的治疗方法失效，并增加了临床治疗的难度。然而，目前尚无针对感染COVID-19的癌症患者的临床治疗方法。由于生物信息学是了解未发现的生物学功能、药理靶点和治疗机制的有效方法。本研究的目的是调查COVID-19感染对癌症患者的影响，并寻找潜在的治疗方法。

方法

首先，我们分别从七个数据库中获取与COVID-19相关的基因，并分析来自基因表达综合数据库（GEO）的癌症致病基因。通过维恩分析展示癌症/COVID-19相关基因。此外，我们阐述了癌症/COVID-19中致病基因的信号通路和生物学功能。

结果

通过GEPIA我们确定Go-Ichi-Ni-San复合物亚基1（GINS1）是癌症/COVID-19中的潜在治疗靶点。GINS1的高表达不仅促进癌症的发展，还影响其预后。此外，通过CMap和分子对接分析确定了癌症/COVID-19的八种潜在化合物。

结论

我们首次揭示GINS1是感染COVID-19的癌症患者的潜在治疗靶点，因为COVID-19将是一场严重且持久的大流行。然而，这些发现尚未在实际感染COVID-19的癌症患者中得到验证，需要进一步研究来证明GINS1的功能和这些化合物的临床治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8b1/9714252/e50f75339044/41065_2022_258_Fig9_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8b1/9714252/e50f75339044/41065_2022_258_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8b1/9714252/29079598a221/41065_2022_258_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8b1/9714252/5971f7e96a8c/41065_2022_258_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8b1/9714252/cb9218f2014e/41065_2022_258_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8b1/9714252/7639151a1bfd/41065_2022_258_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8b1/9714252/7457bbbcc852/41065_2022_258_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8b1/9714252/46483380bd60/41065_2022_258_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8b1/9714252/61e4e2808696/41065_2022_258_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8b1/9714252/e50f75339044/41065_2022_258_Fig9_HTML.jpg

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