Martin J B, Durand D, Gurd W, Faille G, Audet J, Brazeau P
Endocrinology. 1978 Jan;102(1):106-13. doi: 10.1210/endo-102-1-106.
The effects on GH and PRL secretion of several pharmacological agents known to modify central neurotransmitter action were determined in unanesthetized male rats. Phenoxybenzamine, an alpha-adrenergic blocker (5 mg/kg iv), abolished episodic GH secretion and caused elevation of serum PRL levels. Propranolol, a beta-adrenergic blocker (5 mg/kg iv), had no effect on GH secretion and caused a small but significant depression in PRL levels. Parachlorophenylalanine methyl ester, an inhibitor of tryptophan hydroxylase (300-350 mg/kg ip), resulted in significant inhibition of GH pulsatile secretion and suppressed PRL levels. Methysergide hydrogen maleinate (25 mg/kg iv), a serotonin receptor antagonist, also inhibited GH secretion, but produced a transient stimulation in PRL levels. Atropine sulfate (2 mg/kg iv) caused significant suppression in GH secretion, but had no effect on PRL. Picrotoxin, a gamma-aminobutyric acid antagonist, in a subconvulsive dose of 1-3 mg/kg iv, also depressed GH episodic secretion but did not affect PRL levels. These results indicate that several neurotransmitters, i.e., norepinephrine, serotonin, acetylcholine, and gamma-aminobutyric acid, found in high concentration in the hypothalamus, influence GH and PRL secretion.
在未麻醉的雄性大鼠中，测定了几种已知可改变中枢神经递质作用的药理剂对生长激素（GH）和催乳素（PRL）分泌的影响。酚苄明，一种α-肾上腺素能阻滞剂（静脉注射5mg/kg），消除了GH的脉冲式分泌并导致血清PRL水平升高。普萘洛尔，一种β-肾上腺素能阻滞剂（静脉注射5mg/kg），对GH分泌无影响，但导致PRL水平出现轻微但显著的下降。对氯苯丙氨酸甲酯，一种色氨酸羟化酶抑制剂（腹腔注射300 - 350mg/kg），导致GH脉冲式分泌显著受抑并抑制PRL水平。马来酸氢麦角隐亭（静脉注射25mg/kg），一种5-羟色胺受体拮抗剂，也抑制GH分泌，但使PRL水平产生短暂升高。硫酸阿托品（静脉注射2mg/kg）导致GH分泌显著受抑，但对PRL无影响。苦味毒，一种γ-氨基丁酸拮抗剂，静脉注射1 - 3mg/kg的亚惊厥剂量，也抑制GH的脉冲式分泌，但不影响PRL水平。这些结果表明，在下丘脑中高浓度存在的几种神经递质，即去甲肾上腺素、5-羟色胺、乙酰胆碱和γ-氨基丁酸，影响GH和PRL的分泌。
