Collu R, Du Rusisseau P, Taché Y
Neuroendocrinology. 1979;28(3):178-86. doi: 10.1159/000122860.
Immobilization for 30 min induced a significant rise of prolactin (Prl), a significant reduction of growth hormone (GH), and no modification of plasma luteinizing hormone (LH) values in male rats. Depletion of brain catecholamine stores increased Prl and decreased LH levels while GH secretion was not affected. Blockade of beta-adrenergic receptors reduced GH and increased LH values. Plasma GH levels were also drastically reduced by depletion of brain serotonin (SER) levels and by atropine, and were increased by blockade of the H1 histamine (HIS) receptor. The anti-gamma-aminobutyric acid (GABA) agent picrotoxin significantly reduced Prl and GH plasma levels. Depletion of brain catecholamine stores or blockade of beta-adrenergic receptors antagonized the restraint-induced rise of plasma Prl values, while the decrease of GH elicited by stress was not modified by any pharmacological manipulation. These results indicate that although several putative neurotransmitters (PN) of the central nervous system (CNS) are implicated in the modulation of baseline levels of Prl, GH and LH, only the stress-induced activation of Prl secretion appears to be mediated by a PN, namely through a noradrenergic, beta-adrenergic route.
对雄性大鼠固定30分钟可导致催乳素（Prl）显著升高、生长激素（GH）显著降低，而血浆黄体生成素（LH）值无变化。脑儿茶酚胺储备耗竭会使Prl升高、LH水平降低，而GH分泌不受影响。β-肾上腺素能受体阻断会降低GH并升高LH值。脑血清素（SER）水平耗竭和阿托品也会使血浆GH水平大幅降低，而H1组胺（HIS）受体阻断则会使其升高。抗γ-氨基丁酸（GABA）剂印防己毒素可显著降低血浆Prl和GH水平。脑儿茶酚胺储备耗竭或β-肾上腺素能受体阻断可拮抗固定诱导的血浆Prl值升高，而应激引起的GH降低不受任何药理操作的影响。这些结果表明，尽管中枢神经系统（CNS）的几种假定神经递质（PN）参与了Prl、GH和LH基线水平的调节，但只有应激诱导的Prl分泌激活似乎由一种PN介导，即通过去甲肾上腺素能、β-肾上腺素能途径。
