通过苯乙烯的 1,2-二胺化反应进行区域选择性的三组分合成邻二胺。
Regioselective Three-Component Synthesis of Vicinal Diamines via 1,2-Diamination of Styrenes.
机构信息
College of Chemistry, Fuzhou University, 2 Xueyuan Road, Fuzhou, Fujian 350108, P. R. China.
Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, State Key Laboratory of Structural Chemistry, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155 Yangqiao Road West, Fuzhou, Fujian 350002, P. R. China.
出版信息
Org Lett. 2021 Apr 16;23(8):3184-3189. doi: 10.1021/acs.orglett.1c00898. Epub 2021 Apr 1.
The vicinal diamine motif plays a significant role in natural products, drug design, and organic synthesis, and development of synthetic methods for the synthesis of diamines is a long-standing interest. Herein, we report a regioselective intermolecular three-component vicinal diamination of styrenes with acetonitrile and azodicarboxylates. The diamination products can be produced in moderate to excellent yields via the Ritter reaction. Synthetic applications and theoretical studies of this reaction have been conducted.
偕二胺基在天然产物、药物设计和有机合成中具有重要作用，因此开发合成二胺的方法一直是人们关注的焦点。在此，我们报告了一种通过苯乙烯、乙腈和偶氮二甲酸酯的区域选择性分子间邻位三组分二胺化反应。通过 Ritter 反应可以中等至优异的产率得到二胺化产物。我们对该反应进行了合成应用和理论研究。
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