Ellen & Martin Prosserman Centre for Neuromuscular Diseases, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Muscle Nerve. 2021 Jun;63(6):831-836. doi: 10.1002/mus.27243. Epub 2021 Apr 19.
INTRODUCTION/AIMS: The aim of the study was to determine the association between the virtual Myasthenia Gravis Impairment Index (vMGII) with other patient-reported outcomes (PROs) of myasthenia gravis (MG) and its usefulness in telephone consultations with MG patients.
This was a retrospective case series in which vMGII score along with virtual Single Simple Question (vSSQ), virtual Patient-Acceptable Symptom State PASS (vPASS) response, and patient disease status based on Myathenia Gravis Foundation of America postintervention status were collected during telephone consultation along with the MGII, SSQ, and PASS responses during the preceding in-person clinic visits.
In 214 patients, the mean difference of vMGII between the vPASS "Yes" and "No" groups was -14.2 ± 1.4 (95% confidence interval, -16.9 to -11.3; P < .001) with mean vMGII for vPASS "Yes" group being 6.4 ± 7.7 and vPASS "No" being 20.5 ± 11.5. A vMGII of 11.5 or higher predicted vPASS "yes" response with a sensitivity of 78.7% and specificity of 81.4%. A strong negative correlation was found between the vMGII and vSSQ (r = -.667; P < .001). The mean vMGII was 0.48 ± 1.42 for patients in remission, and 9.31 ± 10.93 for improved, 9.32 ± 8.79 for stable, and 22.58 ± 14.04 for worsened groups (P < .001). These associations were the same as those obtained during the preceding in-person clinic visit and the direction of change in MGII scores also indicated change in disease status.
vMGII is an effective measure to assess an MG patient's disease status in telephone consultations and relates well with other PRO measures. The vMGII remains reliable for assessing MG disease status even with removal of the physical examination component.
简介/目的：本研究旨在确定虚拟重症肌无力损伤指数（vMGII）与重症肌无力（MG）其他患者报告结局（PRO）之间的关联，以及其在与 MG 患者的电话咨询中的实用性。
这是一项回顾性病例系列研究，在此项研究中，在电话咨询期间收集了 vMGII 评分以及虚拟单简单问题（vSSQ）、虚拟患者可接受症状状态 PASS（vPASS）应答、基于美国重症肌无力基金会干预后状态的患者疾病状态，同时还收集了在之前的门诊就诊期间的 MGII、SSQ 和 PASS 应答。
在 214 例患者中，vPASS“是”和“否”组之间的 vMGII 平均差异为-14.2±1.4（95%置信区间，-16.9 至-11.3；P<0.001），vPASS“是”组的平均 vMGII 为 6.4±7.7，vPASS“否”组为 20.5±11.5。vMGII 为 11.5 或更高可预测 vPASS“是”应答，其敏感性为 78.7%，特异性为 81.4%。vMGII 与 vSSQ 之间存在强烈的负相关（r=-0.667；P<0.001）。缓解组患者的平均 vMGII 为 0.48±1.42，改善组为 9.31±10.93，稳定组为 9.32±8.79，恶化组为 22.58±14.04（P<0.001）。这些关联与之前在门诊就诊时获得的关联相同，并且 MGII 评分的变化方向也表明疾病状态的变化。
vMGII 是评估电话咨询中 MG 患者疾病状态的有效措施，与其他 PRO 测量方法密切相关。即使没有体检部分，vMGII 仍然可以可靠地评估 MG 疾病状态。
