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脂质泡超声联合抗癌药物增强妇科宫颈癌的抗肿瘤活性。

Enhanced antitumor activity of combined lipid bubble ultrasound and anticancer drugs in gynecological cervical cancers.

机构信息

Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.

Department of Obstetrics and Gynecology, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan.

出版信息

Cancer Sci. 2021 Jun;112(6):2493-2503. doi: 10.1111/cas.14907. Epub 2021 May 1.

DOI:10.1111/cas.14907
PMID:33793049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8177762/
Abstract

Chemotherapy plays an important role in the treatment of patients with gynecological cancers. Delivering anticancer drugs effectively to tumor cells with just few side effects is key in cancer treatment. Lipid bubbles (LB) are compounds that increase the vascular permeability of the tumor under diagnostic ultrasound (US) exposure and enable the effective transport of drugs to tumor cells. The aim of our study was to establish a novel drug delivery technique for chemotherapy and to identify the most effective anticancer drugs for the bubble US-mediated drug delivery system (BUS-DDS) in gynecological cancer treatments. We constructed xenograft models using cervical cancer (HeLa) and uterine endometrial cancer (HEC1B) cell lines. Lipid bubbles were injected i.v., combined with either cisplatin (CDDP), pegylated liposomal doxorubicin (PLD), or bevacizumab, and US was applied to the tumor. We compared the enhanced chemotherapeutic effects of these drugs and determined the optimal drugs for BUS-DDS. Tumor volume reduction of HeLa and HEC1B xenografts following cisplatin treatment was significantly enhanced by BUS-DDS. Both CDDP and PLD significantly enhanced the antitumor effects of BUS-DDS in HeLa tumors; however, volume reduction by BUS-DDS was insignificant when combined with bevacizumab, a humanized anti-vascular endothelial growth factor mAb. The BUS-DDS did not cause any severe adverse events and significantly enhanced the antitumor effects of cytotoxic drugs. The effects of bevacizumab, which were not as dose-dependent as those of the two drugs used prior, were minimal. Our data suggest that BUS-DDS technology might help achieve "reinforced targeting" in the treatment of gynecological cancers.

摘要

化疗在妇科癌症患者的治疗中起着重要作用。将抗癌药物有效地递送到肿瘤细胞，同时副作用较少，是癌症治疗的关键。脂质体（LB）是一种化合物，在诊断超声（US）暴露下可增加肿瘤的血管通透性，并使药物有效地输送到肿瘤细胞。我们的研究目的是建立一种新的化疗药物递送技术，并确定用于妇科癌症治疗的LB-US 介导的药物递送系统（BUS-DDS）中最有效的抗癌药物。我们使用宫颈癌（HeLa）和子宫内膜癌（HEC1B）细胞系构建了异种移植模型。静脉内注射脂质体，与顺铂（CDDP）、聚乙二醇化脂质体阿霉素（PLD）或贝伐单抗联合，并对肿瘤施加 US。我们比较了这些药物增强化疗效果，并确定了 BUS-DDS 的最佳药物。顺铂治疗后，HeLa 和 HEC1B 异种移植瘤的体积减少明显通过 BUS-DDS 增强。CDDP 和 PLD 均显著增强了 BUS-DDS 在 HeLa 肿瘤中的抗肿瘤作用；然而，当与贝伐单抗（一种人源化抗血管内皮生长因子 mAb）联合使用时，BUS-DDS 对肿瘤体积的减少作用不明显。BUS-DDS 未引起任何严重的不良反应，并显著增强了细胞毒性药物的抗肿瘤作用。与之前使用的两种药物相比，贝伐单抗的作用不那么依赖于剂量，其作用最小。我们的数据表明，BUS-DDS 技术可能有助于实现妇科癌症治疗中的“强化靶向”。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/283c/8177762/b263060e1efe/CAS-112-2493-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/283c/8177762/50633203999e/CAS-112-2493-g005.jpg
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本文引用的文献

1
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Gynecol Oncol. 2019 Nov;155(2):331-339. doi: 10.1016/j.ygyno.2019.08.028. Epub 2019 Sep 5.
2
Effects of encapsulated gas on stability of lipid-based microbubbles and ultrasound-triggered drug delivery.包封气体对基于脂质的微泡稳定性和超声触发药物递送的影响。
J Control Release. 2019 Oct;311-312:65-73. doi: 10.1016/j.jconrel.2019.08.023. Epub 2019 Aug 25.
3
Scale-up production, characterization and toxicity of a freeze-dried lipid-stabilized microbubble formulation for ultrasound imaging and therapy.
聚焦超声与超声刺激微泡在癌症放射治疗增敏中的应用。
Technol Cancer Res Treat. 2023 Jan-Dec;22:15330338231176376. doi: 10.1177/15330338231176376.
4
Ultrasound-targeted microbubble destruction remodels tumour microenvironment to improve immunotherapeutic effect.超声靶向微泡破坏重塑肿瘤微环境以提高免疫治疗效果。
Br J Cancer. 2023 Mar;128(5):715-725. doi: 10.1038/s41416-022-02076-y. Epub 2022 Dec 3.
5
Ultrasound and microbubble-mediated drug delivery and immunotherapy.超声与微泡介导的药物递送及免疫治疗
J Med Ultrason (2001). 2022 Apr 11. doi: 10.1007/s10396-022-01201-x.
规模生产、冻干脂质稳定型微泡制剂的特性和毒性研究及其在超声成像和治疗中的应用。
J Liposome Res. 2020 Sep;30(3):297-304. doi: 10.1080/08982104.2019.1649282. Epub 2019 Aug 7.
4
Phase II trial of paclitaxel, carboplatin, and bevacizumab for advanced or recurrent cervical cancer.紫杉醇、卡铂和贝伐单抗治疗晚期或复发性宫颈癌的 II 期临床试验。
Gynecol Oncol. 2019 Sep;154(3):554-557. doi: 10.1016/j.ygyno.2019.05.018. Epub 2019 Jul 5.
5
Ultrasound Molecular Imaging: Principles and Applications in Cardiovascular Medicine.超声分子影像学：心血管医学中的原理与应用。
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6
Cervical Cancer, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology.《宫颈癌（第 3.2019 版）》，NCCN 肿瘤学临床实践指南。
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7
Sonopermeation to improve drug delivery to tumors: from fundamental understanding to clinical translation.声渗透增强肿瘤药物递送：从基础理解到临床转化。
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Crit Care Med. 2018 Sep;46(9):e912-e920. doi: 10.1097/CCM.0000000000003255.
10
The European Society of Gynaecological Oncology/European Society for Radiotherapy and Oncology/European Society of Pathology Guidelines for the Management of Patients With Cervical Cancer.《欧洲妇科肿瘤学会/欧洲放射肿瘤学会/欧洲病理学会宫颈癌管理指南》。
Int J Gynecol Cancer. 2018 May;28(4):641-655. doi: 10.1097/IGC.0000000000001216.