使用路易体痴呆模块（LBD-MOD）对路易体痴呆（DLB）和轻度认知障碍进行特征描述。
Characterization of dementia with Lewy bodies (DLB) and mild cognitive impairment using the Lewy body dementia module (LBD-MOD).
机构信息
Comprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Department of Mathematical Sciences, Florida Atlantic University, Boca Raton, Florida, USA.
出版信息
Alzheimers Dement. 2021 Oct;17(10):1675-1686. doi: 10.1002/alz.12334. Epub 2021 Apr 1.
INTRODUCTION
The National Institute on Aging Alzheimer's Disease Research Center program added the Lewy body dementia module (LBD-MOD) to the Uniform Data Set to facilitate LBD characterization and distinguish dementia with Lewy bodies (DLB) from Alzheimer's disease (AD). We tested the performance of the LBD-MOD.
METHODS
The LBD-MOD was completed in a single-site study in 342 participants: 53 controls, 78 AD, and 110 DLB; 79 mild cognitive impairment due to AD (MCI-AD); and 22 MCI-DLB.
RESULTS
DLB differed from AD in extrapyramidal symptoms, hallucinations, apathy, autonomic features, REM sleep behaviors, daytime sleepiness, cognitive fluctuations, timed attention tasks, and visual perception. MCI-DLB differed from MCI-AD in extrapyramidal features, mood, autonomic features, fluctuations, timed attention tasks, and visual perception. Descriptive data on LBD-MOD measures are provided for reference.
DISCUSSION
The LBD-MOD provided excellent characterization of core and supportive features to differentiate DLB from AD and healthy controls while also characterizing features of MCI-DLB.
简介
美国国家老龄化研究所阿尔茨海默病研究中心项目将路易体痴呆模块（LBD-MOD）添加到统一数据集，以促进 LBD 特征描述，并将路易体痴呆（DLB）与阿尔茨海默病（AD）区分开来。我们测试了 LBD-MOD 的性能。
方法
LBD-MOD 在一个单站点的 342 名参与者中完成：53 名对照、78 名 AD 和 110 名 DLB；79 名 AD 引起的轻度认知障碍（MCI-AD）；和 22 名 MCI-DLB。
结果
DLB 在锥体外系症状、幻觉、冷漠、自主特征、REM 睡眠行为、白天嗜睡、认知波动、定时注意力任务和视觉感知方面与 AD 不同。MCI-DLB 在锥体外系特征、情绪、自主特征、波动、定时注意力任务和视觉感知方面与 MCI-AD 不同。提供了 LBD-MOD 测量的描述性数据供参考。
讨论
LBD-MOD 提供了对核心和支持特征的出色描述，可将 DLB 与 AD 和健康对照组区分开来，同时还可描述 MCI-DLB 的特征。
Zotero 插件