内脂素、内皮抑素、成纤维细胞生长因子-α、肝细胞生长因子和血小板反应蛋白-2在 nAMD 患者房水中的水平升高。

Elevated Levels of Endoglin, Endostatin, FGF-α, HGF, and Thrombospondin-2 in Aqueous Humor of nAMD Patients.

机构信息

Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China.

Department of Head and Neck Surgery, the Affiliated Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China.

出版信息

Ocul Immunol Inflamm. 2022 Jul;30(5):1092-1098. doi: 10.1080/09273948.2020.1869785. Epub 2021 Apr 1.

DOI:10.1080/09273948.2020.1869785

PMID:33793358

Abstract

PURPOSE

to explore the aqueous cytokine profiles in nAMD patients before and after conbercept therapy.

METHODS

aqueous levels of 17 cytokines were detected in 20 treatment-naïve nAMD eyes and 20 age- and sex-matched age-related cataract (ARC) eyes. All of the nAMD patients received three intravitreal injections of conbercept. The central macular thickness (CMT) and maximum retinal thickness-3 mm (MRT-3 mm) were measured by SD-OCT. Fundus fluorescein angiography (FA) was used to measure the greatest linear diameter (GLD).

RESULTS

Aqueous endoglin, endostatin, FGF-α, HGF, and thrombospondin-2 levels were significantly higher in the nAMD group than those in the ARC group, whether before or after two conbercept injections. In the nAMD group, baseline thrombospondin-2 was positively correlated with GLD. Baseline FGF-α, thrombospondin-2, and VEGF-A were positively correlated with MRT-3 mm. After two conbercept injections, endostatin levels were positively correlated with VEGF-A.

CONCLUSIONS

Endoglin, endostatin, FGF-α, HGF, and thrombospondin-2 may participate in the pathogenesis of nAMD.

摘要

目的

探讨康柏西普治疗 nAMD 患者前后房水中细胞因子的变化。

方法

本研究纳入了 20 例未经治疗的 nAMD 患者和 20 例年龄和性别匹配的年龄相关性白内障（ARC）患者。所有 nAMD 患者均接受了三次康柏西普玻璃体腔内注射。采用 SD-OCT 测量中心黄斑厚度（CMT）和最大视网膜厚度-3mm（MRT-3mm）。荧光素眼底血管造影（FA）用于测量最大线性直径（GLD）。

结果

在接受或不接受两次康柏西普治疗后，nAMD 组房水中的内皮糖蛋白、内皮抑素、FGF-α、HGF 和血栓素-2 水平均显著高于 ARC 组。在 nAMD 组中，基线血栓素-2与 GLD 呈正相关。基线 FGF-α、血栓素-2 和 VEGF-A 与 MRT-3mm 呈正相关。在接受两次康柏西普治疗后，内皮抑素水平与 VEGF-A 呈正相关。